di Frega Antonio Scotto, Dale Brian, Di Matteo Loredana, Wilding Martin
Centre for Reproductive Biology, Clinica Villa del Sole, Via Manzoni, 15, 80126 Naples, Italy.
Hum Reprod. 2005 Apr;20(4):997-8. doi: 10.1093/humrep/deh707. Epub 2004 Dec 23.
Surgical treatments such as the Roux-en-Y gastric bypass operation result in the successful treatment of morbid obesity; however, this type of operation may cause long-term side effects due to the reduced absorption of nutrients. Here, we present data suggesting that this operation can result in secondary infertility in males. Six healthy, previously fertile male subjects presented in our centre for secondary infertility after a Roux-en-Y gastric bypass operation for morbid obesity. Reproductive function was assessed with a series of spermiograms, and by testicular biopsy. Secondary azoospermy with complete spermatogenic arrest was diagnosed. The results suggest that weight reduction surgery may cause reproductive dysfunction.
诸如胃旁路手术等外科治疗方法能成功治疗病态肥胖症；然而，由于营养物质吸收减少，这类手术可能会导致长期副作用。在此，我们提供的数据表明，这种手术会导致男性继发性不孕。六名健康且既往有生育能力的男性因病态肥胖接受胃旁路手术后，到我们中心就诊，出现继发性不孕。通过一系列精液检查和睾丸活检对生殖功能进行了评估。诊断为继发性无精子症伴完全生精停滞。结果表明，减重手术可能会导致生殖功能障碍。
