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The future of dengue vaccines.登革热疫苗的未来。
Lancet. 2002 Oct 19;360(9341):1243-5. doi: 10.1016/S0140-6736(02)11276-1.
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Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever.登革热1型抗体对美洲登革热2型病毒感染及登革出血热的影响。
Lancet. 2002 Jul 27;360(9329):310-2. doi: 10.1016/S0140-6736(02)09522-3.
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Do escape mutants explain rapid increases in dengue case-fatality rates within epidemics?逃逸突变体能否解释登革热疫情期间病死率的快速上升？
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Chimeric yellow fever virus 17D-Japanese encephalitis virus vaccine: dose-response effectiveness and extended safety testing in rhesus monkeys.嵌合黄热病病毒17D-日本脑炎病毒疫苗：恒河猴的剂量反应有效性及扩展安全性测试
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Dengue virus structural differences that correlate with pathogenesis.与发病机制相关的登革病毒结构差异。
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Affinity-purified dengue-2 virus envelope glycoprotein induces neutralizing antibodies and protective immunity in mice.
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Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.与美洲地区致病性增加相关的登革2型病毒的起源。
Virology. 1997 Apr 14;230(2):244-51. doi: 10.1006/viro.1997.8504.
9
Partial nucleotide and amino acid sequences of the envelope and the envelope/nonstructural protein-1 gene junction of four dengue-2 virus strains isolated during the 1981 Cuban epidemic.1981年古巴登革热疫情期间分离出的4株登革热2型病毒包膜蛋白以及包膜蛋白/非结构蛋白1基因连接处的部分核苷酸和氨基酸序列。
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Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralization.采用半微量法在BHK-21细胞中进行登革病毒简化蚀斑减少中和试验：BHK悬浮试验与标准蚀斑减少中和试验的比较
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免疫小鼠对登革2型病毒亚洲和美洲基因型的抗体反应。

Antibody responses to Asian and American genotypes of dengue 2 virus in immunized mice.

作者信息

Bernardo Lidice, Yndart Adriana, Vázquez Susana, Morier Luis, Guzmán María G

机构信息

Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía, Km 6, Havana, Cuba.

出版信息

Clin Diagn Lab Immunol. 2005 Feb;12(2):361-2. doi: 10.1128/CDLI.12.2.361-362.2005.

DOI:10.1128/CDLI.12.2.361-362.2005
PMID:15699435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC549307/
Abstract

The possibility of a correlation between dengue virus genotype groups and disease severity is currently under discussion. The objective of this investigation was to identify any immunogenic difference between the American and Asian dengue 2 virus genotypes through the study of antibody development (virus-binding immunoglobulin G and neutralizing antibodies) in mice. Differences in the neutralization pattern between the strains studied were observed, suggesting the presence of slight antigenic variations among them. The lack of recognition of one of the Asian genotype strains was remarkable.

摘要

登革热病毒基因型组与疾病严重程度之间存在关联的可能性目前正在讨论中。本研究的目的是通过研究小鼠体内抗体的产生（病毒结合免疫球蛋白G和中和抗体）来确定美洲和亚洲登革热2型病毒基因型之间的任何免疫原性差异。在所研究的毒株之间观察到中和模式的差异，表明它们之间存在轻微的抗原变异。值得注意的是，其中一种亚洲基因型毒株未被识别。