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在优化的滑行条件下，抗体的抑制作用揭示了P1黏附素参与肺炎支原体的滑行运动。

Involvement of P1 adhesin in gliding motility of Mycoplasma pneumoniae as revealed by the inhibitory effects of antibody under optimized gliding conditions.

作者信息

Seto Shintaro, Kenri Tsuyoshi, Tomiyama Tetsuo, Miyata Makoto

机构信息

Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585, Japan.

出版信息

J Bacteriol. 2005 Mar;187(5):1875-7. doi: 10.1128/JB.187.5.1875-1877.2005.

DOI:10.1128/JB.187.5.1875-1877.2005
PMID:15716461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1064011/
Abstract

To examine the participation of P1 adhesin in gliding of Mycoplasma pneumoniae, we examined the effects of an anti-P1 monoclonal antibody on individual gliding mycoplasmas. The antibody reduced the gliding speed and removed the gliding cells from the glass over time in a concentration-dependent manner but had only a slight effect on nongliding cells, suggesting that the conformational changes of P1 adhesin and its displacement are involved in the gliding mechanism.

摘要

为了研究P1黏附素在肺炎支原体滑行中的作用，我们检测了抗P1单克隆抗体对单个滑行支原体的影响。随着时间的推移，该抗体以浓度依赖的方式降低了滑行速度，并使滑行的细胞从玻璃表面脱落，但对非滑行细胞只有轻微影响，这表明P1黏附素的构象变化及其移位参与了滑行机制。

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本文引用的文献

1
Cell surface differentiation of Mycoplasma mobile visualized by surface protein localization.通过表面蛋白定位观察运动支原体的细胞表面分化
Microbiology (Reading). 2004 Dec;150(Pt 12):4001-8. doi: 10.1099/mic.0.27436-0.
2
Use of fluorescent-protein tagging to determine the subcellular localization of mycoplasma pneumoniae proteins encoded by the cytadherence regulatory locus.利用荧光蛋白标记法确定由黏附调节基因座编码的肺炎支原体蛋白的亚细胞定位。
J Bacteriol. 2004 Oct;186(20):6944-55. doi: 10.1128/JB.186.20.6944-6955.2004.
3
Spike structure at the interface between gliding Mycoplasma mobile cells and glass surfaces visualized by rapid-freeze-and-fracture electron microscopy.通过快速冷冻断裂电子显微镜观察到的滑行运动的运动支原体细胞与玻璃表面界面处的刺突结构。
J Bacteriol. 2004 Jul;186(13):4382-6. doi: 10.1128/JB.186.13.4382-4386.2004.
4
Energetics of gliding motility in Mycoplasma mobile.运动支原体滑行运动的能量学
J Bacteriol. 2004 Jul;186(13):4254-61. doi: 10.1128/JB.186.13.4254-4261.2004.
5
Identification of a 349-kilodalton protein (Gli349) responsible for cytadherence and glass binding during gliding of Mycoplasma mobile.鉴定一种负责运动支原体滑行过程中细胞黏附和玻璃黏附的349千道尔顿蛋白（Gli349）。
J Bacteriol. 2004 Mar;186(5):1537-45. doi: 10.1128/JB.186.5.1537-1545.2004.
6
Cellular engineering in a minimal microbe: structure and assembly of the terminal organelle of Mycoplasma pneumoniae.极小微生物中的细胞工程：肺炎支原体末端细胞器的结构与组装
Mol Microbiol. 2004 Feb;51(4):917-24. doi: 10.1046/j.1365-2958.2003.03899.x.
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Attachment organelle formation represented by localization of cytadherence proteins and formation of the electron-dense core in wild-type and mutant strains of Mycoplasma pneumoniae.以肺炎支原体野生型和突变株中细胞黏附蛋白的定位及电子致密核心的形成为代表的附着细胞器形成。
J Bacteriol. 2003 Feb;185(3):1082-91. doi: 10.1128/JB.185.3.1082-1091.2003.
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Movement on the cell surface of the gliding bacterium, Mycoplasma mobile, is limited to its head-like structure.滑行细菌移动支原体的细胞表面运动仅限于其头部样结构。
FEMS Microbiol Lett. 2002 Oct 8;215(2):285-9. doi: 10.1111/j.1574-6968.2002.tb11404.x.
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Adhesion and inhibition assay of Mycoplasma genitalium and M. pneumoniae by immunofluorescence microscopy.通过免疫荧光显微镜对生殖支原体和肺炎支原体进行黏附与抑制试验。
J Med Microbiol. 2002 May;51(5):361-373. doi: 10.1099/0022-1317-51-5-361.
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Force and velocity of mycoplasma mobile gliding.运动支原体滑行的力与速度。
J Bacteriol. 2002 Apr;184(7):1827-31. doi: 10.1128/JB.184.7.1827-1831.2002.