Rodriguez-Morán Martha, Guerrero-Romero Fernando
Medical Research Unit in Clinical Epidemiology, General Hospital of the Mexican Social Security Institute, Mexico.
Magnes Res. 2004 Sep;17(3):189-96.
The aim of this study was to determine the relationship between serum magnesium and TNF-alpha levels in obese subjects. A cross-sectional population based study that included 192 non-diabetic, non-hypertensive subjects allocated in three categories of body mass index (BMI) <25; > or =25 to <30 kg/m2; and > or =30 kg/m2. Elevation of TNF-alpha levels was defined by serum levels > or =3.5 pg/mL, and low serum magnesium by levels < or = 0.74 mmol/L. Multivariate odds ratios (OR) adjusted by age, HOMA-IR index, and glucose tolerance status are presented. Obese subjects exhibited higher serum concentration of TNF-alpha (p = 0.002) and lower serum magnesium levels (p < 0.0001) than lean and overweight subjects. Ninety-one (47.4%) subjects showed elevated levels of TNF-alpha, of them 7 (10.9%), 31 (48.4%), and 43 (67.2%) in the groups with BMI <25, > or = 25 to < 0, and >> or =0 kg/m2, respectively. Multivariate OR between low serum magnesium and TNF-alpha levels in obese subjects was of 1.8, Cl95% 1.2-9.1, P = 0.001, whereas in the lean and overweight individuals of 1.1, Cl95% 0.7-8.7, P = 0.12, and 1.3, Cl95% 0.9-10.8, P = 0.09, respectively. These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects. It will be necessary to conduct more studies in order to add new data on this issue.
本研究的目的是确定肥胖受试者血清镁与肿瘤坏死因子-α（TNF-α）水平之间的关系。这是一项基于人群的横断面研究，纳入了192例非糖尿病、非高血压受试者，根据体重指数（BMI）分为三类：<25；≥25至<30kg/m²；以及≥30kg/m²。TNF-α水平升高定义为血清水平≥3.5pg/mL，血清镁水平低定义为≤0.74mmol/L。给出了经年龄、稳态模型评估的胰岛素抵抗（HOMA-IR）指数和糖耐量状态调整后的多因素比值比（OR）。与瘦人和超重受试者相比，肥胖受试者的血清TNF-α浓度更高（p = 0.002），血清镁水平更低（p < 0.0001）。91例（47.4%）受试者的TNF-α水平升高，其中BMI<25、≥25至<30以及≥30kg/m²组中分别有7例（10.9%）、31例（48.4%）和43例（67.2%）。肥胖受试者中低血清镁与TNF-α水平之间的多因素OR为1.8，95%置信区间（Cl95%）为1.2 - 9.1，P = 0.001，而在瘦人和超重个体中分别为1.1，Cl95% 0.7 - 8.7，P = 0.12，以及1.3，Cl95% 0.9 - 10.8，P = 0.09。这些数据表明，肥胖受试者中血清镁水平低与TNF-α升高有关。有必要进行更多研究以增加关于此问题的新数据。
