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本文引用的文献

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THE MULTIPLICATION OF BACTERIOPHAGE IN VIVO AND ITS PROTECTIVE EFFECT AGAINST AN EXPERIMENTAL INFECTION WITH SHIGELLA DYSENTERIAE.噬菌体在体内的繁殖及其对志贺氏痢疾杆菌实验感染的保护作用。
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Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.一株耐万古霉素金黄色葡萄球菌高耐菌株的基因分析
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Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11.新型噬菌体phi MR11对小鼠致死性金黄色葡萄球菌感染的实验性保护作用
J Infect Dis. 2003 Feb 15;187(4):613-24. doi: 10.1086/374001. Epub 2003 Feb 7.
4
Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran-treated mice.右旋糖酐铁治疗小鼠中由创伤弧菌引起的局部和全身性疾病的噬菌体疗法
Infect Immun. 2002 Nov;70(11):6251-62. doi: 10.1128/IAI.70.11.6251-6262.2002.
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Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium.噬菌体疗法可挽救因耐万古霉素屎肠球菌临床分离株而发生菌血症的小鼠。
Infect Immun. 2002 Jan;70(1):204-10. doi: 10.1128/IAI.70.1.204-210.2002.
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Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail.噬菌体对黄尾鱼实验性海豚链球菌感染的保护作用。
Dis Aquat Organ. 1999 Jun 23;37(1):33-41. doi: 10.3354/dao037033.
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Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves.利用裂解性噬菌体控制鸡和犊牛实验性大肠杆菌败血症和脑膜炎
Clin Diagn Lab Immunol. 1998 May;5(3):294-8. doi: 10.1128/CDLI.5.3.294-298.1998.
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Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa.噬菌体可防止铜绿假单胞菌对皮肤移植物的破坏。
Burns. 1994 Jun;20(3):209-11. doi: 10.1016/0305-4179(94)90184-8.
9
Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection.在一种新型异物感染实验小鼠模型中,甲氧西林和庆大霉素治疗的效果。
Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53. doi: 10.1128/AAC.38.9.2047.
10
Successful treatment of experimental Escherichia coli infections in mice using phage: its general superiority over antibiotics.利用噬菌体成功治疗小鼠实验性大肠杆菌感染:其相对于抗生素的总体优势。
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兔模型中实验性噬菌体对金黄色葡萄球菌脓肿的防护作用

Experimental bacteriophage protection against Staphylococcus aureus abscesses in a rabbit model.

作者信息

Wills Quintin F, Kerrigan Claire, Soothill James S

机构信息

Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, UK.

出版信息

Antimicrob Agents Chemother. 2005 Mar;49(3):1220-1. doi: 10.1128/AAC.49.3.1220-1221.2005.

DOI:10.1128/AAC.49.3.1220-1221.2005
PMID:15728933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC549253/
Abstract

In a rabbit model of wound infection caused by Staphylococcus aureus, 2 x 10(9) PFU of staphylococcal phage prevented abscess formation in rabbits when it was injected simultaneously with S. aureus (8 x 10(7) CFU) into the same subcutaneous site. Phage multiplied in the tissues. Phages might be a valuable prophylaxis against staphylococcal infection.

摘要

在由金黄色葡萄球菌引起的兔伤口感染模型中,当将2×10⁹噬菌斑形成单位(PFU)的葡萄球菌噬菌体与金黄色葡萄球菌(8×10⁷菌落形成单位,CFU)同时注射到同一皮下部位时,可预防兔体内脓肿形成。噬菌体在组织中增殖。噬菌体可能是预防葡萄球菌感染的一种有价值的手段。