来自马达加斯加刺果树的双降三萜类化合物。
Bisnortriterpenes from Salacia madagascariensis.
作者信息
Thiem Deborah A, Sneden Albert T, Khan Shabana I, Tekwani Babu L
机构信息
Department of Chemistry, Virginia Commonwealth University, P.O. Box 842006, Richmond, VA 23284-2006, USA.
出版信息
J Nat Prod. 2005 Feb;68(2):251-4. doi: 10.1021/np0497088.
PMID:15730255
Abstract
A new bisnortriterpene quinone methide, 20-epi-isoiguesterinol (2), and a new 6-oxophenolic triterpene, 6-oxoisoiguesterin (5), as well as two known compounds, isoiguesterin (1) and isoiguesterinol (4), were isolated from the petroleum ether extract of the roots of Salacia madagascariensis. Isoiguesterin (1) and 20-epi-isoiguesterinol (2) showed potent activity against Leishmania.
摘要
从马达加斯加刺果番荔枝根的石油醚提取物中分离出一种新的双降三萜醌甲基化物20-表异异钩藤醇（2）、一种新的6-氧代酚类三萜6-氧代异异钩藤素素（5），以及两种已知化合物异异钩藤素（1）和异异钩藤醇（4）。异异钩藤素（1）和20-表异异钩藤醇（2）对利什曼原虫显示出强效活性。
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