Falsey A R, Walsh E E
Department of Medicine, Rochester General Hospital, New York 14621.
J Med Virol. 1992 Jan;36(1):39-43. doi: 10.1002/jmv.1890360108.
The relationship between serum immunoglobulins and the severity and risk of Respiratory Syncytial Virus (RSV) infection in the institutionalized elderly was prospectively assessed during the winter of 1989-1990 at a 591 bed nursing home. Forty RSV infections were identified out of 149 respiratory illnesses by isolation of the virus or by a greater than or equal to 4-fold rise in RSV-specific IgG by EIA. Acute serum RSV IgG levels were similar in those with RSV infection and those with non-RSV illness. Additionally, among the RSV-infected elderly there was no correlation between severity of clinical symptoms and level of acute IgG titers by EIA or virus neutralization. The results of this study suggest that humoral immunity does not play a major role in reducing the risk of infection nor modulating the clinical severity of illness in elderly persons with RSV infections.
1989 - 1990年冬季，在一家拥有591张床位的养老院中，对机构养老老年人血清免疫球蛋白与呼吸道合胞病毒（RSV）感染的严重程度及风险之间的关系进行了前瞻性评估。通过病毒分离或酶免疫测定法检测到呼吸道合胞病毒特异性IgG升高4倍及以上，在149例呼吸道疾病中确定了40例RSV感染。RSV感染患者和非RSV疾病患者的急性血清RSV IgG水平相似。此外，在感染RSV的老年人中，临床症状的严重程度与酶免疫测定法或病毒中和法检测的急性IgG滴度水平之间没有相关性。本研究结果表明，体液免疫在降低感染风险或调节RSV感染老年人疾病的临床严重程度方面不起主要作用。
