Petrella Robert John, Lattanzio Chastity Nina, Demeray Amy, Varallo Vincent, Blore Rachel
Department of Family Medicine, Faculty of Medicine, School of Kinesiology, University of Western Ontario, London, Ontario, Canada.
Diabetes Care. 2005 Mar;28(3):694-701. doi: 10.2337/diacare.28.3.694.
To determine the impact of chronic exercise training initiated later in life upon development of metabolic markers of cardiovascular disease risk.
Two inception cohorts of previously sedentary healthy adults aged 55-75 years at baseline (1989), one initiating regular supervised physical exercise training and the other a geographical similar sedentary control, were assessed for anthropometric, biochemical, and clinical markers of the metabolic syndrome and comorbidity over 10 years.
At baseline, active individuals aged 68 years compared with sedentary individuals aged 67 years had similar fitness levels (5.7 vs. 5.8 metabolic equivalents). At follow-up, complete data were obtained for 161 active and 136 sedentary subjects. Drop out occurred primarily because of failure to adhere to the exercise regimen and poor physical health for active and sedentary individuals, respectively. More metabolic abnormalities were seen in the sedentary group than in the active group for one or two (64 vs. 36%, P < 0.001) and three or more (35 vs. 22%, P < 0.003) abnormalities, respectively. In those assessed at follow-up, the sedentary group compared with the active group had lower fitness levels (5.0 [13.8% decrease] vs. 5.9 [3.5% increase] metabolic equivalents), had a greater likelihood of a positive exercise electrocardiogram or symptom (32 vs. 10%, P < 0.001), and had more comorbid conditions (Charlson Comorbidity Index score 0.9 vs. 0.4, P < 0.01).
Higher fitness achieved over 10 years of regular exercise training in older adults was associated with reduced development of metabolic risk factors for cardiovascular disease, fewer exercise-induced cardiac abnormalities, and reduced comorbidity.
确定晚年开始的慢性运动训练对心血管疾病风险代谢标志物发展的影响。
两个初始队列，基线时（1989年）为55 - 75岁以前久坐不动的健康成年人，一组开始进行有监督的定期体育锻炼训练，另一组为地理上类似的久坐对照组，在10年期间对代谢综合征和合并症的人体测量、生化和临床标志物进行评估。
基线时，68岁的活跃个体与67岁的久坐个体相比，健身水平相似（5.7与5.8代谢当量）。随访时，获得了161名活跃受试者和136名久坐受试者的完整数据。失访主要分别是因为活跃个体未坚持运动方案以及久坐个体身体健康状况不佳。久坐组出现一或两项（64%对36%，P < 0.001）和三项或更多（35%对22%，P < 0.003）代谢异常的情况比活跃组更多。在随访评估的人群中，久坐组与活跃组相比，健身水平较低（5.0[下降13.8%]对5.9[增加3.5%]代谢当量），运动心电图或症状呈阳性的可能性更大（32%对10%，P < 0.001），合并症更多（Charlson合并症指数评分0.9对0.4，P < 0.01）。
老年人通过10年定期运动训练获得的较高健身水平与心血管疾病代谢危险因素的发展减少、运动诱发的心脏异常减少以及合并症减少有关。
