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意大利G4血清型人轮状病毒的基因变异性

Genetic variability among serotype G4 Italian human rotaviruses.

作者信息

Arista S, Giammanco G M, De Grazia S, Colomba C, Martella V

机构信息

Dipartimento di Igiene e Microbiologia, Università di Palermo, via del Vespro 133, 90127 Palermo, Italy.

出版信息

J Clin Microbiol. 2005 Mar;43(3):1420-5. doi: 10.1128/JCM.43.3.1420-1425.2005.

Abstract

A total of 254 serotype GH rotavirus strains were detected in Palermo, Italy, from 1985 to 2003. Out of 38 serotype G4 strains selected for genetic analysis, 14 were recognized by genotyping as type G9. Strains confirmed to belong to the G4 type showed temporal patterns of genetic evolution in their VP7 and VP4 gene sequences, and the latest Italian G4 strains were distantly related to the reference vaccinal ST3 strain.

摘要

1985年至2003年期间,在意大利巴勒莫共检测到254株GH血清型轮状病毒毒株。在挑选出用于基因分析的38株G4血清型毒株中,有14株通过基因分型被鉴定为G9型。经确认属于G4型的毒株在其VP7和VP4基因序列中呈现出遗传进化的时间模式,并且意大利最新的G4毒株与参考疫苗株ST3亲缘关系较远。

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