Chuang Shao-Yuan, Chen Chen-Huan, Chou Pesus
Community Medicine Research Center, National Yang-Ming University School of Medicine, Taiwan, ROC.
J Chin Med Assoc. 2004 Dec;67(12):611-20.
Metabolic syndrome is a major risk factor for cardiovascular disease and the development of type 2 diabetes. The purpose of the present study was to investigate the prevalence of metabolic syndrome in a large health check-up population in Taiwan.
During the period of 2000-2001, about 120,000 adults aged 20 years and above received health check-ups at the MJ Health Screening Centers. Among these, 24,329 participants with complete data on waist circumference, blood pressure, fasting levels of glucose, triglyceride, and high-density-lipoprotein cholesterol were randomly selected for analysis. The prevalence of metabolic syndrome was estimated according to the criteria proposed by the National Cholesterol Education Program (NCEP III), with adoption of the Asian criteria for abdominal obesity.
Based on the strict NCEP III criteria, the prevalence of metabolic syndrome was 9.5% (10.6% in men and 8.1% in women, respectively); with Asian criteria for waist circumference, 12.9% (15.5% in men and 10.5% in women, respectively). The prevalence of metabolic syndrome increased with age. Prevalences of all components of metabolic syndrome increased sharply with age in women. In contrast, the prevalences of high triglyceride and low high-density-lipoprotein cholesterol flattened and declined after the age of 50 years in men. Therefore, the gender difference resulted in a cross-over of the prevalence of metabolic syndrome between men and women at the age of 60 years.
The prevalence of metabolic syndrome in a physical check-up population is significantly affected by age and gender. Age- and gender-specific strategies may be useful in the control of the syndrome.
代谢综合征是心血管疾病和2型糖尿病发生的主要危险因素。本研究的目的是调查台湾大规模健康检查人群中代谢综合征的患病率。
在2000年至2001年期间,约120,000名20岁及以上的成年人在美兆健康检查中心接受了健康检查。其中,随机选择了24,329名腰围、血压、空腹血糖、甘油三酯和高密度脂蛋白胆固醇数据完整的参与者进行分析。根据美国国家胆固醇教育计划(NCEP III)提出的标准,并采用亚洲腹部肥胖标准来估计代谢综合征的患病率。
基于严格的NCEP III标准,代谢综合征的患病率为9.5%(男性为10.6%,女性为8.1%);采用亚洲腰围标准时,患病率为12.9%(男性为15.5%,女性为10.5%)。代谢综合征的患病率随年龄增长而增加。女性代谢综合征所有组分的患病率均随年龄急剧上升。相比之下,男性甘油三酯升高和高密度脂蛋白胆固醇降低的患病率在50岁后趋于平稳并下降。因此,性别差异导致60岁时男性和女性代谢综合征患病率出现交叉。
体检人群中代谢综合征的患病率受年龄和性别的显著影响。针对年龄和性别的策略可能有助于控制该综合征。