冠状动脉血流缓慢患者的血小板功能障碍
Platelet function disorder in patients with coronary slow flow.
作者信息
Gökçe Mustafa, Kaplan Sahin, Tekelioğlu Yavuz, Erdoğan Turan, Küçükosmanoğlu Mehmet
机构信息
Department of Cardiology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
出版信息
Clin Cardiol. 2005 Mar;28(3):145-8. doi: 10.1002/clc.4960280310.
BACKGROUND
Some patients evaluated for chest pain with angiographically normal coronary arteries show coronary slow flow phenomenon (CSFP) on angiography. Slow flow of dye in epicardial coronary arteries is also not an infrequent finding in patients during routine coronary angiography. The precise pathophysiology of CSFP is not known yet.
HYPOTHESIS
This study investigates the presence of platelet function disorders in patients with CSFP.
METHODS
The patient group included 24 patients with CSFP detected by coronary angiography via the TIMI "frame count" method, and a control group included 23 patients with normal coronary flow. Platelet aggregability induced by use of ristocetin, collagen, and adenosine diphosphate (ADP), was measured from all blood samples in both control and patient groups.
RESULTS
The ratio of platelet aggregability increased significantly in patients with CSFP compared with patients with normal coronary flow (ristocetin 57.6 +/- 15 vs. 45.4 +/- 17.1, collagen 62.9 +/- 16.4 vs. 48.9 +/- 25.3, ADP 59.4 +/- 18 vs. 42.4 +/- 15.2, p < 0.05).
CONCLUSION
Platelet aggregability is increased in patients with CSFP.
背景
一些接受胸痛评估且冠状动脉造影显示正常的患者在血管造影时表现出冠状动脉血流缓慢现象（CSFP）。在常规冠状动脉造影过程中，患者心外膜冠状动脉内染料流动缓慢也并非罕见发现。CSFP的确切病理生理学尚不清楚。
假设
本研究调查CSFP患者中血小板功能障碍的存在情况。
方法
患者组包括24例通过冠状动脉造影采用TIMI“帧数计数”法检测出CSFP的患者，对照组包括23例冠状动脉血流正常的患者。对对照组和患者组的所有血样均测量了使用瑞斯托霉素、胶原和二磷酸腺苷（ADP）诱导的血小板聚集性。
结果
与冠状动脉血流正常的患者相比，CSFP患者的血小板聚集性比率显著升高（瑞斯托霉素：57.6±15对45.4±17.1，胶原：62.9±16.4对48.9±25.3，ADP：59.4±18对42.4±15.2，p<0.05）。
结论
CSFP患者的血小板聚集性增加。
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