扫视速度作为2型脊髓小脑共济失调的替代疾病标志物。
Saccade velocity as a surrogate disease marker in spinocerebellar ataxia type 2.
作者信息
Seifried C, Velázquez-Pérez L, Santos-Falcón N, Abele M, Ziemann U, Almaguer L E, Martínez-Góngora E, Sánchez-Cruz G, Canales N, Pérez-González R, Velázquez-Manresa M, Viebahn B, Stuckrad-Barre S, Klockgether T, Fetter M, Auburger G
机构信息
Clinic for Neurology, University Hospital, Frankfurt, am Main, Germany.
出版信息
Ann N Y Acad Sci. 2005 Apr;1039:524-7. doi: 10.1196/annals.1325.059.
PMID:15827014
Abstract
We measured in 82 spinocerebellar ataxia type 2 (SCA2) patients and in 80 controls maximal saccade velocity (MSV) and correlated it to polyglutamine expansion size and disease duration. MSV is strongly decreased in SCA2 patients and is influenced mostly by polyglutamine size.
摘要
我们对82例2型脊髓小脑共济失调（SCA2）患者和80名对照者测量了最大扫视速度（MSV），并将其与多聚谷氨酰胺扩展长度及病程进行关联分析。SCA2患者的MSV显著降低，且主要受多聚谷氨酰胺长度的影响。
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