Sharma A, Inagaki S, Honma K, Sfintescu C, Baker P J, Evans R T
Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA.
J Dent Res. 2005 May;84(5):462-7. doi: 10.1177/154405910508400512.
Tannerella forsythia (formerly Bacteroides forsythus) is one of the periodontal pathogens recently implicated in the development of periodontal disease. The cell-surface-associated, as well as the secreted, leucine-rich-repeat protein (BspA) of this bacterium have been suggested to play roles in bacterial adherence, and also in inflammation, by triggering release of pro-inflammatory cytokines from monocytes and chemokines from osteoblasts, leading to inflammation and bone resorption. In this study, we sought to determine the pathogenic potential of T. forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T. forsythia wild-type strain, whereas the BspA mutant was impaired. In conclusion, evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium.
福赛坦氏菌（以前称为福赛拟杆菌）是最近被认为与牙周病发展有关的牙周病原体之一。该细菌的细胞表面相关以及分泌的富含亮氨酸重复序列蛋白（BspA）被认为在细菌黏附中起作用，并且通过触发单核细胞释放促炎细胞因子和成骨细胞释放趋化因子，在炎症中也发挥作用，从而导致炎症和骨吸收。在本研究中，我们试图确定福赛坦氏菌的致病潜力以及BspA蛋白在感染诱导的牙槽骨丢失小鼠模型发病机制中的体内作用。结果显示，感染福赛坦氏菌野生型菌株的小鼠出现牙槽骨丢失，而BspA突变体则受损。总之，有证据支持福赛坦氏菌是参与诱导牙槽骨丢失的重要生物体，并且BspA蛋白是该细菌的重要毒力因子。
