Eibensteiner Lynn, Del Carpio Sanz Ada, Frumkin Howard, Gonzales Carla, Gonzales Gustavo F
Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
Int J Occup Environ Health. 2005 Apr-Jun;11(2):161-6. doi: 10.1179/oeh.2005.11.2.161.
This study examined lead exposure (n = 43) and semen quality (n = 18) among traffic police officers in Arequipa, Peru, where leaded gasoline is used. Blood lead (PbB) was measured using atomic absorption spectrophotometry, and semen was analyzed following World Health Organization (WHO) protocol. Mean PbB was 48.5 microg/dL. Although current PbB was associated with declines in several semen parameters (sperm morphology, concentration and total number of sperm), only sperm motility and viability differed significantly between the < or = 40 microg/dL and > 40 microg/dL categories, and decreased with increasing PbB in simple linear regression. Traffic police are an indicator group for excessive ambient lead exposure, and these results support earlier findings on the male reproductive toxicity of lead. The results should be interpreted cautiously since the numbers were small and the analysis was unable to control for all potential confounders due to incomplete data.
本研究调查了秘鲁阿雷基帕市使用含铅汽油地区交警的铅暴露情况（n = 43）和精液质量（n = 18）。采用原子吸收分光光度法测量血铅（PbB），并按照世界卫生组织（WHO）的方案分析精液。平均血铅水平为48.5微克/分升。虽然当前血铅水平与多个精液参数（精子形态、浓度和精子总数）的下降有关，但只有精子活力和存活率在血铅水平≤40微克/分升和＞40微克/分升两组之间存在显著差异，且在简单线性回归中随血铅水平升高而降低。交警是环境铅暴露过量的一个指示群体，这些结果支持了先前关于铅对男性生殖毒性的研究发现。由于样本量较小且因数据不完整分析无法控制所有潜在混杂因素，对结果的解释应谨慎。
