Che Xiao-Yan, Qiu Li-Wen, Liao Zhi-Yong, Wang Ya-di, Wen Kun, Pan Yu-Xian, Hao Wei, Mei Ya-Bo, Cheng Vincent C C, Yuen Kwok-Yung
Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
J Infect Dis. 2005 Jun 15;191(12):2033-7. doi: 10.1086/430355. Epub 2005 May 6.
Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.
针对不同人类冠状病毒(HCoV)的抗体之间的交叉反应尚未得到系统研究。通过蛋白质印迹分析、间接免疫荧光测定(IFA)和酶联免疫吸附测定(ELISA),在免疫动物和人血清中证实了严重急性呼吸综合征(SARS)相关冠状病毒(SARS-CoV)与两种HCoV(229E和OC43)之间的抗原交叉反应。在11例SARS患者中的5例以及11例中的10例中,通过IFA检测,配对血清样本显示针对HCoV-229E和HCoV-OC43的抗体滴度分别升高了≥4倍。总体而言,曾患SARS的康复患者的血清样本与两种已知HCoV存在单向交叉反应。SARS-CoV和HCoV-OC43的抗原比SARS-CoV和HCoV-229E的抗原具有更强的交叉反应性。