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通过矩阵模型对RNA结构进行枚举

Enumeration of RNA structures by matrix models.

作者信息

Vernizzi Graziano, Orland Henri, Zee A

机构信息

Service de Physique Théorique, CEA Saclay, 91191 Gif-sur-Yvette Cedex, France.

出版信息

Phys Rev Lett. 2005 Apr 29;94(16):168103. doi: 10.1103/PhysRevLett.94.168103.

Abstract

We enumerate the number of RNA contact structures according to their genus, i.e., the topological character of their pseudoknots. By using a recently proposed matrix model formulation for the RNA folding problem, we obtain exact results for the simple case of an RNA molecule with an infinitely flexible backbone, in which any arbitrary pair of bases is allowed. We analyze the distribution of the genus of pseudoknots as a function of the total number of nucleotides along the phosphate-sugar backbone.

摘要

我们根据RNA接触结构的亏格来枚举其数量,即它们假结的拓扑特征。通过使用最近提出的用于RNA折叠问题的矩阵模型公式,我们得到了具有无限柔性主链的RNA分子这一简单情况下的精确结果,其中任意一对碱基都是允许的。我们分析了假结亏格的分布作为沿磷酸 - 核糖主链核苷酸总数的函数。

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