克拉迪诺醇A，一种源自海洋真菌粘帚霉属的聚酮糖苷。

Cladionol A, a polyketide glycoside from marine-derived fungus Gliocladium species.

作者信息

Kasai Yuu, Komatsu Kazusei, Shigemori Hideyuki, Tsuda Masashi, Mikami Yuzuru, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

J Nat Prod. 2005 May;68(5):777-9. doi: 10.1021/np050046b.

DOI:10.1021/np050046b

PMID:15921429

Abstract

A new polyketide glycoside, cladionol A (1), was isolated from the cultured broth of a fungus Gliocladium sp., which was separated from sea grass Syringodium isoetifolium, and the structure was elucidated by spectroscopic data. The relative stereochemistry of C-2-C-3 was assigned by mainly J-based configuration analysis, while those of two sugar units were elucidated to be beta-mannopyranoside and arabitol on the basis of NOESY data and/or 1H-1H couplings. Furthermore, the absolute configuration of the mannose moiety was determined as the D-form on the basis of chiral HPLC analysis of a benzoyl derivative of the acid hydrolysate of 1. Cladionol A (1) exhibited modest cytotoxicity.

摘要

从一种与异叶海菖蒲分离得到的真菌粘帚霉属（Gliocladium sp.）的培养液中分离出一种新的聚酮糖苷，即枝顶孢醇A（1），并通过光谱数据阐明了其结构。C-2-C-3的相对立体化学主要通过基于J值的构型分析确定，而两个糖单元的相对立体化学则根据NOESY数据和/或1H-1H偶合确定为β-甘露吡喃糖苷和阿拉伯糖醇。此外，基于1的酸水解产物的苯甲酰衍生物的手性HPLC分析，甘露糖部分的绝对构型被确定为D型。枝顶孢醇A（1）表现出适度的细胞毒性。