Kaptein Ad-A, Morita Satoshi, Sakamoto Junichi
Psychology Unit, Leiden University Medical Center (LUMC), PO Box 9555, 2300 RB Leiden, The Netherlands.
World J Gastroenterol. 2005 Jun 7;11(21):3189-96. doi: 10.3748/wjg.v11.i21.3189.
To summarize the empirical research on assessing quality of life (QOL) in patients with gastric carcinoma.
Literature searches were conducted in MedLine from 1966 to February 2004.
Twenty-six studies were identified. QOL was used as an outcome measure in virtually all identified studies, such as those examining the effects of gastric cancer and various medical or surgical treatments in the patients. QOL was assessed mainly with generic measures; the social dimensions of QOL were largely neglected. The lack of gastric cancer-specific QOL measures hampers QOL research up to now. The gastric cancer-specific EORTC-QLQ-STO22 and the FACT-Ga are important additions to the arsenal of disease-specific QOL measures. In most of the studies, the label QOL is used for questionnaires, which only assess symptoms or performance status, or are physician-reported rather than patient-reported outcomes.
QOL in patients with gastric cancer deserves more systematic studies, especially as one of the outcome measures in randomized clinical trials. Results of studies that include QOL in patients with gastric cancer should be applied in clinical care, which aims at improving QOL of these patients.
总结评估胃癌患者生活质量（QOL）的实证研究。
在1966年至2004年2月期间对MedLine进行文献检索。
共识别出26项研究。在几乎所有已识别的研究中，生活质量都被用作一项结果指标，比如那些考察胃癌及各种医学或手术治疗对患者影响的研究。生活质量主要通过通用指标进行评估；生活质量的社会维度在很大程度上被忽视了。缺乏针对胃癌的生活质量测量方法至今仍阻碍着生活质量研究。针对胃癌的欧洲癌症研究与治疗组织生活质量问卷核心模块-胃癌22量表（EORTC-QLQ-STO22）和癌症治疗功能评价系统-胃癌量表（FACT-Ga）是疾病特异性生活质量测量方法中的重要补充。在大多数研究中，生活质量这一标签被用于仅评估症状或功能状态、或是由医生报告而非患者报告结果的问卷。
胃癌患者的生活质量值得进行更系统的研究，尤其是作为随机临床试验的结果指标之一。纳入胃癌患者生活质量的研究结果应应用于临床护理中，其目的在于改善这些患者的生活质量。
