Straatman Jennifer, van der Wielen Nicole, Joosten Pieter J, Terwee Caroline B, Cuesta Miguel A, Jansma Elise P, van der Peet Donald L
Department of Gastrointestinal Surgery, VU University Medical Center, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Surg Endosc. 2016 May;30(5):1920-9. doi: 10.1007/s00464-015-4415-3. Epub 2015 Aug 27.
Gastric cancer is responsible for 10 % of all cancer-related deaths worldwide. With improved operative techniques and neo-adjuvant therapy, survival rates are increasing. Outcomes of interest are shifting to quality of life (QOL), with many different tools available. The aim of this study was to assess which patient-reported outcome measures (PROMs) are used to measure QOL after a gastrectomy for cancer.
A comprehensive search was conducted for original articles investigating QOL after gastrectomy. Two authors independently selected relevant articles, conducted clinical appraisal and extracted data (P.J. and J.S.).
Out of 3414 articles, 26 studies were included, including a total of 4690 patients. These studies included ten different PROMs, which could be divided into generic, symptom-specific and disease-specific questionnaires. The EORTC and the FACT questionnaires use an oncological overall QOL module and an organ-specific module. Only one validation study regarding the use of the EORTC after surgery for gastric cancer was available, demonstrating good psychometric properties and clinical validity.
A great variety of PROMs are being used in the measurement of QOL after surgery for gastric cancer. A questionnaire with a general module along with a disease-specific module for the assessment of QOL seems most desirable, such as the EORTC and the FACT with their specific modules. Both are developed in different treatment modalities, such as in surgical patients. EORTC is the most widely used questionnaire and therefore allows for comparison of new studies to existing data. Future studies are needed to assess content validity in surgical gastric cancer patients.
在全球范围内，胃癌导致的死亡占所有癌症相关死亡的10%。随着手术技术的改进和新辅助治疗的应用，生存率正在提高。人们关注的结果正转向生活质量（QOL），并且有许多不同的工具可供使用。本研究的目的是评估哪些患者报告结局指标（PROMs）用于测量癌症胃切除术后的生活质量。
对调查胃切除术后生活质量的原始文章进行全面检索。两位作者独立选择相关文章、进行临床评估并提取数据（P.J.和J.S.）。
在3414篇文章中，纳入了26项研究，共涉及4690例患者。这些研究包括10种不同的PROMs，可分为通用问卷、症状特异性问卷和疾病特异性问卷。欧洲癌症研究与治疗组织（EORTC）和癌症治疗功能评估（FACT）问卷使用肿瘤学总体生活质量模块和器官特异性模块。仅有一项关于胃癌手术后使用EORTC的验证研究，显示出良好的心理测量特性和临床有效性。
在测量胃癌手术后的生活质量时，使用了各种各样的PROMs。一个带有通用模块以及用于评估生活质量的疾病特异性模块的问卷似乎是最理想的，例如EORTC和FACT及其特定模块。两者均是在不同治疗模式下开发的，如手术患者。EORTC是使用最广泛的问卷，因此可以将新研究与现有数据进行比较。未来需要开展研究来评估手术胃癌患者的内容效度。
