Globe Denise R, Varma Rohit, Torres Mina, Wu Joanne, Klein Ronald, Azen Stanley P
Department of Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, USA.
Arch Ophthalmol. 2005 Jun;123(6):815-21. doi: 10.1001/archopht.123.6.815.
To assess the association of self-reported systemic and ocular comorbid disease and visual function in Latino subjects.
National Eye Institute 25-item Visual Function Questionnaire (NEI-VFQ-25) and eye examination data were obtained from 5380 participants in the Los Angeles Latino Eye Study, a population-based prevalence study of eye disease in Latino subjects 40 years and older. We developed and contrasted 5 comorbidity measures. One-way analysis of variance was used to assess the association between comorbidity and visual impairment and self-reported visual function. Regression analyses determined the association of sociodemographic variables, clinical variables, and the best measure of comorbidity with the NEI-VFQ-25 composite score. The main outcome measure was self-reported visual function as assessed by the NEI-VFQ-25 composite score.
On average, visual function subscale scores were lowest for those participants with the most systemic comorbid conditions (P<.05). This was more evident in participants with moderate or severe visual impairment compared with those with mild or no visual impairment (P<.05).
Self-reported systemic comorbidities were associated with self-reported visual function. This association was greater at more severe levels of visual impairment. Of the 5 comorbidity measures assessed, the measure that summed the number of self-reported systemic comorbidities correlated most with self-reported visual function.
评估拉丁裔受试者自我报告的全身和眼部合并症与视觉功能之间的关联。
从洛杉矶拉丁裔眼病研究的5380名参与者中获取了国立眼科研究所25项视觉功能问卷（NEI-VFQ-25）和眼部检查数据，该研究是一项针对40岁及以上拉丁裔受试者眼病的基于人群的患病率研究。我们制定并对比了5种合并症测量方法。采用单因素方差分析来评估合并症与视力损害及自我报告的视觉功能之间的关联。回归分析确定了社会人口统计学变量、临床变量以及合并症的最佳测量方法与NEI-VFQ-25综合评分之间的关联。主要结局指标是通过NEI-VFQ-25综合评分评估的自我报告的视觉功能。
平均而言，全身合并症最多的参与者的视觉功能子量表得分最低（P<0.05）。与轻度或无视力损害的参与者相比，中度或重度视力损害的参与者中这种情况更为明显（P<0.05）。
自我报告的全身合并症与自我报告的视觉功能相关。在更严重的视力损害水平下，这种关联更强。在所评估的5种合并症测量方法中，汇总自我报告的全身合并症数量的测量方法与自我报告的视觉功能相关性最高。
