Van Dooren Sonia, Meertens Laurent, Lemey Philippe, Gessain Antoine, Vandamme Anne-Mieke
Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Unité d'Epidémiologie des Virus Oncogènes, Département EEMI, Institut Pasteur, Paris, France.
J Gen Virol. 2005 Jul;86(Pt 7):1953-1959. doi: 10.1099/vir.0.80520-0.
Full-genome sequencing and analysis of the highly divergent simian T-cell lymphotropic virus type 1 (STLV-1) strain MarB43 in Macaca arctoides indicated that its open reading frame structure is compatible with proper functioning of its Gag, Pol, Env, Tax and Rex proteins. Detailed analysis of the coding potential, however, revealed that MarB43 is probably forced to use the human T-cell lymphotropic virus type 2/STLV-2 env-tax-rex splice-acceptor homologue and that the proximal pX auxiliary proteins p12(I), p13(II), p30(II) and p27(I) seem to have lost their function. Full-genome (gag-pol-env-tax), long terminal repeat and env phylogenetic analyses conclusively identified STLV-1 in M. arctoides as the currently most divergent STLV-1 strain. The long branching pattern of the monophyletic STLV-1 Macaca subspecies clades suggests that macaques might be the ancestral reservoir for primate T-cell lymphotropic virus type 1 in Asia. Full-genome molecular-clock analysis supports an archaic introduction of STLV-1 on the Asian continent, at least 269 000-156 000 years ago.
对熊猴体内高度分化的1型猿猴嗜T细胞病毒（STLV-1）毒株MarB43进行全基因组测序和分析表明，其开放阅读框结构与其Gag、Pol、Env、Tax和Rex蛋白的正常功能相匹配。然而，对编码潜能的详细分析显示，MarB43可能被迫使用2型人类嗜T细胞病毒/STLV-2 env-tax-rex剪接受体同源物，并且近端pX辅助蛋白p12(I)、p13(II)、p30(II)和p27(I)似乎已丧失其功能。全基因组（gag-pol-env-tax）、长末端重复序列和env系统发育分析最终确定熊猴体内的STLV-1为目前分歧最大的STLV-1毒株。单系STLV-1猕猴亚种分支的长分支模式表明，猕猴可能是亚洲1型灵长类嗜T细胞病毒的原始宿主。全基因组分子钟分析支持STLV-1至少在269,000 - 156,000年前在亚洲大陆的古老引入。
