口服补充维生素C对血液透析患者氧化应激和炎症状态的影响。
Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients.
作者信息
Fumeron Christine, Nguyen-Khoa Thao, Saltiel Claudine, Kebede Messeret, Buisson Claude, Drüeke Tilman B, Lacour Bernard, Massy Ziad A
机构信息
AURA Centre Henri Küntziger, INSERM ERI-12, Amiens University Hospital and University of Picardie, Amiens, France.
出版信息
Nephrol Dial Transplant. 2005 Sep;20(9):1874-9. doi: 10.1093/ndt/gfh928. Epub 2005 Jun 21.
BACKGROUND
There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients.
METHODS
We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 mg three times per week) for 2 months on well-defined oxidative and inflammatory markers in 33 chronic haemodialysis (HD) patients.
RESULTS
Normalization of plasma total vitamin C and ascorbate levels by oral vitamin C supplementation did not modify plasma levels of carbonyls, C-reactive protein and albumin, or erythrocyte concentrations of reduced and oxidized glutathione.
CONCLUSION
Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined.
背景
越来越多的证据表明透析患者存在氧化应激和维生素C缺乏。然而，关于补充维生素C对这类患者氧化应激和炎症标志物影响的数据有限。
方法
我们进行了一项前瞻性、随机、开放标签试验，以评估口服维生素C补充剂（每周三次，每次250毫克）2个月对33例慢性血液透析（HD）患者明确的氧化和炎症标志物的影响。
结果
口服维生素C补充剂使血浆总维生素C和抗坏血酸盐水平恢复正常，但并未改变血浆羰基、C反应蛋白和白蛋白水平，也未改变红细胞中还原型和氧化型谷胱甘肽的浓度。
结论
短期口服维生素C补充剂并未改变HD患者明确的氧化/抗氧化应激和炎症标志物。更高的口服剂量或静脉途径是否能改变这些标志物仍有待确定。
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