Iacobellis Gianluca, Ribaudo Maria Cristina, Zappaterreno Alessandra, Iannucci Concetta Valeria, Leonetti Frida
Center for Human Nutrition, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9052, USA.
Obes Res. 2005 Jun;13(6):1116-22. doi: 10.1038/oby.2005.130.
The existence of healthy obese subjects has been suggested but not clearly reported. We sought to address the prevalence of uncomplicated obesity and adverse risk factors in a large Italian obese population.
This was a cross-sectional study of a population of consecutive Italian obese subjects. We studied 681 obese subjects (514 women and 167 men), with a mean age of 41.1+/-13.9 years (range, 16 to 77 years), mean BMI of 40.2+/-7.6 kg/m2 (range, 30 to 89.8 kg/m2), and a history of obesity for 20.5+/-7 years (range, 10.5 to 30 years). Anthropometric, metabolic, cardiac, and obesity-related risk factors were evaluated.
The prevalence of uncomplicated subjects was 27.5%, independent of BMI and duration of obesity. The youngest group of obese subjects showed a higher, but not statistically significantly higher, prevalence of uncomplicated obesity. No statistical difference for the prevalence of impaired fasting glucose, glucose intolerance, high triglycerides, high total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol among BMI categories (from mild to extremely severe obesity degree) was found. Obese subjects with BMI>50 kg/m2 showed a higher prevalence of high blood pressure only when they were compared with the group with a BMI of 30 to 35 kg/m2 (p<0.01). Obese subjects with BMI>40 kg/m2 showed a higher prevalence of hyperinsulinemia than subjects with BMI 30 to 35 kg/m2 (p<0.01).
This study shows that a substantial part of an Italian obese population has uncomplicated obesity, and the prevalence of adverse risk factors in this sample is unexpectedly low and partially independent of obesity degree. Uncomplicated obesity could represent a well-defined clinical entity.
已有研究提示存在健康肥胖个体，但尚无明确报道。我们旨在探讨意大利大量肥胖人群中单纯性肥胖的患病率及不良风险因素。
这是一项对意大利连续肥胖个体进行的横断面研究。我们研究了681名肥胖个体（514名女性和167名男性），平均年龄为41.1±13.9岁（范围16至77岁），平均体重指数为40.2±7.6kg/m²（范围30至89.8kg/m²），肥胖病史为20.5±7年（范围10.5至30年）。评估了人体测量学、代谢、心脏及肥胖相关风险因素。
单纯性肥胖个体的患病率为27.5%，与体重指数和肥胖持续时间无关。最年轻的肥胖个体组单纯性肥胖患病率较高，但无统计学显著差异。在不同体重指数类别（从轻度至极度重度肥胖程度）中，空腹血糖受损、葡萄糖耐量异常、高甘油三酯、高总胆固醇、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇患病率无统计学差异。体重指数>50kg/m²的肥胖个体仅在与体重指数为30至35kg/m²的组比较时高血压患病率较高（p<0.01）。体重指数>40kg/m²的肥胖个体高胰岛素血症患病率高于体重指数为30至35kg/m²的个体（p<0.01）。
本研究表明，意大利肥胖人群中有相当一部分为单纯性肥胖，且该样本中不良风险因素的患病率出乎意料地低，且部分与肥胖程度无关。单纯性肥胖可能代表一种明确的临床实体。
