Taniguchi T, Shimazawa M, Araie M, Tomita G, Sasaoka M, Kitazawa Y, Hara H
Research and Development Center, Santen Pharmaceutical Co Ltd, Nara, Japan.
Br J Ophthalmol. 2005 Aug;89(8):1058-62. doi: 10.1136/bjo.2004.062513.
To study optic disc topographic parameters in normal cynomolgus monkeys by Heidelberg retina tomograph (HRT).
12 optic disc topographic parameters were investigated in 36 normal eyes in 18 male monkeys. Mean (SD) and interocular differences were obtained for each parameter from three independent measurements made during a 1 week period. Correlations among the topographic parameters were analysed, too.
No significant differences between right and left eyes were detected for any topographic parameters. Disc area, rim area, and height variation contour showed smaller right-left differences than other parameters. The coefficients of variation for rim area, height variation contour, rim volume, mean cup depth, maximum cup depth, mean retinal nerve fibre layer (RNFL) thickness, and RNFL cross section area were less than 10% (for rim area, less than 5%). Rim area and height variation contour showed relatively weak interrelations and neither showed a correlation with disc area.
For evaluating time related changes in the optic disc by HRT in monkeys, rim area and height variation contour might be useful parameters because coefficients of variation and right-left differences were lower than for other parameters and because these parameters showed weak interrelations and no correlation with disc area.
采用海德堡视网膜断层扫描仪（HRT）研究正常食蟹猴的视盘地形图参数。
对18只雄性猴子的36只正常眼睛的12个视盘地形图参数进行研究。在1周内进行三次独立测量，获取每个参数的平均值（标准差）和两眼间差异。同时分析地形图参数之间的相关性。
任何地形图参数在右眼和左眼之间均未检测到显著差异。视盘面积、盘沿面积和高度变化轮廓的左右差异比其他参数小。盘沿面积、高度变化轮廓、盘沿体积、平均杯深、最大杯深、平均视网膜神经纤维层（RNFL）厚度和RNFL横截面积的变异系数小于10%（盘沿面积小于5%）。盘沿面积和高度变化轮廓显示出相对较弱的相互关系，且均与视盘面积无相关性。
对于通过HRT评估猴子视盘的时间相关变化，盘沿面积和高度变化轮廓可能是有用的参数，因为其变异系数和左右差异低于其他参数，且这些参数显示出较弱的相互关系且与视盘面积无相关性。
