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1
Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor.新生多肽和变性蛋白对热休克基因的调控：热休克蛋白70作为一种潜在的自调控因子
J Cell Biol. 1992 Jun;117(6):1151-9. doi: 10.1083/jcb.117.6.1151.
2
Activation of the heat shock transcription factor by hypoxia in mammalian cells.缺氧对哺乳动物细胞中热休克转录因子的激活作用。
Proc Natl Acad Sci U S A. 1990 Aug;87(16):6263-7. doi: 10.1073/pnas.87.16.6263.
3
Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.尽管热休克因子1被激活，但Y79视网膜母细胞瘤细胞中人类hsp70热休克基因转录的诱导不足。
Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8695-9. doi: 10.1073/pnas.91.18.8695.
4
Effect of thermal stress on early and late passaged mouse lens epithelial cells.热应激对传代早期和晚期的小鼠晶状体上皮细胞的影响。
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5
Genetic regulation during heat shock and function of heat-shock proteins: a review.热休克期间的基因调控与热休克蛋白的功能：综述
Can J Biochem Cell Biol. 1983 Jun;61(6):387-94. doi: 10.1139/o83-053.
6
Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.
Mol Cell Biol. 1991 Jan;11(1):586-92. doi: 10.1128/mcb.11.1.586-592.1991.
7
Stress dose-dependent suppression of heat shock protein gene expression by inhibiting protein synthesis during heat shock treatment.在热休克处理过程中，应激通过抑制蛋白质合成对热休克蛋白基因表达产生剂量依赖性抑制作用。
Cell Struct Funct. 1997 Feb;22(1):7-13. doi: 10.1247/csf.22.7.
8
Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones.热休克因子1（hsf1）的靶向破坏导致耐热性缺失，并确定了应激诱导型热休克蛋白（Hsp）分子伴侣的组织特异性调控。
J Cell Biochem. 2002;86(2):376-93. doi: 10.1002/jcb.10232.
9
Different thresholds in the responses of two heat shock transcription factors, HSF1 and HSF3.两种热休克转录因子HSF1和HSF3反应中的不同阈值。
J Biol Chem. 1997 Jun 13;272(24):15389-95. doi: 10.1074/jbc.272.24.15389.
10
Heat-shock-induced protein synthesis is responsible for the switch-off of hsp70 transcription in Tetrahymena.热休克诱导的蛋白质合成负责关闭四膜虫中的hsp70转录。
Biochim Biophys Acta. 1993 Aug 19;1174(2):133-42. doi: 10.1016/0167-4781(93)90107-o.

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Chaperone Dependency during Primary Protein Biogenesis Does Not Correlate with Chaperone Dependency during Refolding.初级蛋白质生物合成过程中的伴侣蛋白依赖性与重折叠过程中的伴侣蛋白依赖性不相关。
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Role of HSF1 in cell division, tumorigenesis and therapy: a literature review.热休克因子1在细胞分裂、肿瘤发生及治疗中的作用：文献综述
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Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.限制20S蛋白酶体组装会导致26S/30S蛋白酶体在核质分布失衡以及慢性蛋白毒性。
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HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.热休克蛋白 90β 通过调节带电多泡体蛋白 (CHMP4B) 和 p53 预防与衰老相关的白内障形成。
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HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network.热休克因子1：通过将长寿信号整合到蛋白质稳态网络中来守护蛋白质组
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9
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response.缺乏 Hikeshi 在正常情况下会激活 HSF1 的活性，并扰乱热休克反应。
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10
Collective Learnings of Studies of Stress Granule Assembly and Composition.应激颗粒组装和组成研究的综合分析。
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本文引用的文献

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Purification of the major mammalian heat shock proteins.主要哺乳动物热休克蛋白的纯化。
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2
The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels.热休克反应在转录和转录后水平上都是自我调节的。
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Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.在哺乳动物细胞中表达氯霉素乙酰转移酶的重组基因组。
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
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A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene.一种果蝇RNA聚合酶II转录因子与热休克蛋白70（hsp 70）基因的调控位点结合。
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Immunoglobulin heavy chain binding protein.免疫球蛋白重链结合蛋白
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Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.三磷酸腺苷参与70千道尔顿热休克蛋白的核及核仁功能。
EMBO J. 1985 Dec 1;4(12):3137-43. doi: 10.1002/j.1460-2075.1985.tb04056.x.
10
Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.哺乳动物70000道尔顿应激蛋白的快速纯化：这些蛋白对核苷酸的亲和力。
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新生多肽和变性蛋白对热休克基因的调控：热休克蛋白70作为一种潜在的自调控因子

Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor.

作者信息

Baler R, Welch W J, Voellmy R

机构信息

Department of Biochemistry and Molecular Biology, University of Miami, School of Medicine, Florida 33101.

出版信息

J Cell Biol. 1992 Jun;117(6):1151-9. doi: 10.1083/jcb.117.6.1151.

DOI:10.1083/jcb.117.6.1151
PMID:1607379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2289502/
Abstract

Heat shock genes encode proteins (hsp's) that play important structural roles under normal circumstances and are essential to the cells' ability to survive environmental insults. Evidence is presented herein that transcriptional regulation of hsp gene expression is linked with the regulation of overall protein synthesis as well as with the accumulation of proteins denatured by stressful events. The factor that connects the three processes appears to be one of the hsp's, presumably a member(s) of the hsp70 family. Biochemical experiments demonstrate that complexes containing hsp70 and heat shock transcription factor, the specific regulator of hsp gene activity, are formed in the cells.

摘要

热休克基因编码的蛋白质（热休克蛋白）在正常情况下发挥重要的结构作用，对于细胞在环境应激下的生存能力至关重要。本文提供的证据表明，热休克蛋白基因表达的转录调控与整体蛋白质合成的调控以及应激事件导致的变性蛋白的积累有关。连接这三个过程的因素似乎是一种热休克蛋白，推测是热休克蛋白70家族的成员之一。生化实验表明，细胞中形成了包含热休克蛋白70和热休克转录因子（热休克蛋白基因活性的特异性调节因子）的复合物。