高血压与心脏代谢综合征。
Hypertension and the cardiometabolic syndrome.
作者信息
Manrique Camila, Lastra Guido, Whaley-Connell Adam, Sowers James R
机构信息
Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA.
出版信息
J Clin Hypertens (Greenwich). 2005 Aug;7(8):471-6. doi: 10.1111/j.1524-6175.2005.04617.x.
Abstract
Hypertension and cardiovascular disease are leading causes of morbidity and mortality. Accumulating data demonstrate a relationship between hypertension and several vascular and metabolic abnormalities that are components of the cardiometabolic syndrome. The components of the cardiometabolic syndrome include insulin resistance/hyperinsulinemia, central obesity, dyslipidemia, hypertension, microalbuminuria, increased inflammation, and oxidative stress. There is growing evidence that tissue activation of the renin-angiotensin-aldosterone system participates in endothelial dysfunction, microalbuminuria, insulin resistance, and subsequent cardiovascular and chronic kidney disease. The notion that hypertension is a metabolic as well as a vascular disease opens a new paradigm for the treatment of this disorder.
摘要
高血压和心血管疾病是发病和死亡的主要原因。越来越多的数据表明，高血压与几种血管和代谢异常之间存在关联，这些异常是心脏代谢综合征的组成部分。心脏代谢综合征的组成部分包括胰岛素抵抗/高胰岛素血症、中心性肥胖、血脂异常、高血压、微量白蛋白尿、炎症增加和氧化应激。越来越多的证据表明，肾素-血管紧张素-醛固酮系统的组织激活参与了内皮功能障碍、微量白蛋白尿、胰岛素抵抗以及随后的心血管和慢性肾脏疾病。高血压是一种代谢性疾病和血管性疾病的观点为这种疾病的治疗开辟了新的范例。
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