Burch James B, Yost Michael G, Johnson Wendy, Allen Emily
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, USA.
J Occup Environ Med. 2005 Sep;47(9):893-901. doi: 10.1097/01.jom.0000177336.21147.9f.
Night work is associated with disrupted circadian rhythms, fatigue, accidents, and chronic disease. Melatonin secretion helps regulate sleep and circadian rhythms.
Melatonin, sleep disturbances, and symptoms (sleep, fatigue, mental) were compared among workers on permanent day, swing, and night shifts.
Urinary 6-hydroxymelatonin sulfate (6-OHMS) was measured in postwork and postsleep samples. Disrupted circadian melatonin production was evaluated using the sleep:work 6-OHMS ratio. Wrist actigraphy characterized light exposures and sleep characteristics.
Night workers had altered melatonin, disrupted sleep, and elevated symptom prevalence. Subjects grouped by their sleep:work 6-OHMS ratio rather than shift had even greater symptom prevalence. Risks for two or more symptoms were 3.5 to 8 times greater among workers with sleep:work ratios < or =1 compared to those with ratios >1.
This ratio may help identify workers at increased risk for accidents or injuries.
夜间工作与昼夜节律紊乱、疲劳、事故及慢性病有关。褪黑素分泌有助于调节睡眠和昼夜节律。
比较长期日班、轮班和夜班工人的褪黑素、睡眠障碍及症状（睡眠、疲劳、精神方面）。
在工作后和睡眠后的样本中测量尿6-硫酸羟基褪黑素（6-OHMS）。使用睡眠：工作6-OHMS比值评估昼夜褪黑素分泌紊乱情况。手腕活动记录仪记录光照暴露和睡眠特征。
夜班工人的褪黑素改变、睡眠紊乱且症状患病率升高。按睡眠：工作6-OHMS比值而非班次分组的受试者症状患病率更高。睡眠：工作比值≤1的工人出现两种或更多症状的风险比比值>1的工人高3.5至8倍。
该比值可能有助于识别事故或受伤风险增加的工人。
