Hasselmo Michael E, Eichenbaum Howard
Department of Psychology Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St., Boston, MA 02215, USA.
Neural Netw. 2005 Nov;18(9):1172-90. doi: 10.1016/j.neunet.2005.08.007. Epub 2005 Nov 2.
Behaviors ranging from delivering newspapers to waiting tables depend on remembering previous episodes to avoid incorrect repetition. Physiologically, this requires mechanisms for long-term storage and selective retrieval of episodes based on the time of occurrence, despite variable intervals and similarity of events in a familiar environment. Here, this process has been modeled based on the physiological properties of the hippocampal formation, including mechanisms for sustained activity in entorhinal cortex and theta rhythm oscillations in hippocampal subregions. The model simulates the context-sensitive firing properties of hippocampal neurons including trial-specific firing during spatial alternation and trial by trial changes in theta phase precession on a linear track. This activity is used to guide behavior, and lesions of the hippocampal network impair memory-guided behavior. The model links data at the cellular level to behavior at the systems level, describing a physiologically plausible mechanism for the brain to recall a given episode which occurred at a specific place and time.
从送报纸到当服务员等各种行为都依赖于记住先前的事件以避免错误重复。从生理上来说，这需要基于事件发生时间进行长期存储和选择性检索事件的机制，尽管在熟悉环境中事件的间隔和相似性各不相同。在此，这个过程已根据海马结构的生理特性进行建模，包括内嗅皮层持续活动和海马亚区theta节律振荡的机制。该模型模拟了海马神经元的上下文敏感放电特性，包括空间交替期间的试验特异性放电以及在线性轨道上theta相位进动的逐次试验变化。这种活动用于指导行为，海马网络损伤会损害记忆引导行为。该模型将细胞水平的数据与系统水平的行为联系起来，描述了大脑回忆在特定地点和时间发生的给定事件的一种生理上合理的机制。
