Mani F, Damasceno H C R, Novelli E L B, Martins E A M, Sforcin J M
Department of Chemistry and Biochemistry, Biosciences Institute, UNESP, 18600-000 Botucatu, SP, Brazil.
J Ethnopharmacol. 2006 Apr 21;105(1-2):95-8. doi: 10.1016/j.jep.2005.10.011. Epub 2005 Nov 15.
Propolis is a resinous substance produced by honeybees that possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory, among others. The purpose of the present study was to investigate the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Three different treatments were analyzed: (1) rats were treated with different concentrations of propolis (1, 3 and 6 mg/kg/day) during 30 days; (2) rats were treated with 1 mg/kg/day of ethanolic or water extracts of propolis (EEP, WEP) during 30 days; (3) rats were treated with 1 mg/kg/day of ethanolic extract of propolis during 90 and 150 days. Our results demonstrated no alterations in the seric levels of cholesterol, HDL-cholesterol, total lipids, triglycerides and in the specific activity of aminotransferases (AST) and lactic dehydrogenase (LDH) of propolis-treated groups when compared to controls. On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury.
蜂胶是蜜蜂产生的一种树脂状物质，具有许多生物活性，如抗肿瘤、抗氧化、抗菌、抗炎和免疫调节等。本研究的目的是调查经蜂胶处理的大鼠的生化特征，以观察蜂胶给药后是否可能产生副作用。分析了三种不同的处理方式：（1）大鼠在30天内用不同浓度的蜂胶（1、3和6毫克/千克/天）进行处理；（2）大鼠在30天内用1毫克/千克/天的蜂胶乙醇提取物或水提取物（EEP、WEP）进行处理；（3）大鼠在90天和150天内用1毫克/千克/天的蜂胶乙醇提取物进行处理。与对照组相比，我们的结果表明，蜂胶处理组的血清胆固醇、高密度脂蛋白胆固醇、总脂质、甘油三酯水平以及转氨酶（AST）和乳酸脱氢酶（LDH）的比活性均无变化。基于我们的研究结果，由于蜂胶不会引起血清参数的任何显著变化，因此可以认为长期服用蜂胶可能不会造成任何心脏损伤。
