Calder V L, Lightman S L
Department of Clinical Science, Institute of Ophthalmology, London, UK.
Clin Exp Immunol. 1992 Aug;89(2):165-9. doi: 10.1111/j.1365-2249.1992.tb06926.x.
EAU is a model of ocular inflammatory disease. EAU resembles another T cell-mediated autoimmune disease--experimental allergic encephalomyelitis--since both have increased expression of MHC class II molecules in the target tissue, can be adoptively transferred by activated CD4+ T cells and are inhibited by cyclosporin A. The immunological findings will be compared to find out if the same cellular mechanisms are involved in both diseases.
实验性自身免疫性葡萄膜炎（EAU）是一种眼部炎性疾病模型。EAU类似于另一种T细胞介导的自身免疫性疾病——实验性变应性脑脊髓炎，因为两者在靶组织中MHC II类分子的表达均增加，均可由活化的CD4+ T细胞进行过继转移，且均受环孢菌素A抑制。将对这些免疫学发现进行比较，以确定这两种疾病是否涉及相同的细胞机制。
