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症状监测数据能否检测出传染病的局部暴发?一项利用隐孢子虫病历史疫情的模型研究。

Can syndromic surveillance data detect local outbreaks of communicable disease? A model using a historical cryptosporidiosis outbreak.

作者信息

Cooper D L, Verlander N Q, Smith G E, Charlett A, Gerard E, Willocks L, O'Brien S

机构信息

Regional Surveillance Unit, Health Protection Agency West Midlands, Birmingham, UK.

出版信息

Epidemiol Infect. 2006 Feb;134(1):13-20. doi: 10.1017/S0950268805004802.

Abstract

A national UK surveillance system currently uses data from a health helpline (NHS Direct) in an attempt to provide early warning of a bio-terrorist attack, or an outbreak caused by a more common infection. To test this syndromic surveillance system we superimposed data from a historical outbreak of cryptosporidiosis onto a statistical model of NHS Direct call data. We modelled whether calls about diarrhoea (a proxy for cryptosporidiosis) exceeded a statistical threshold, thus alerting the surveillance team to the outbreak. On the date that the public health team were first notified of the outbreak our model predicted a 4% chance of detection when we assumed that one-twentieth of cryptosporidiosis cases telephoned the helpline. This rose to a 72% chance when we assumed nine-tenths of cases telephoned. The NHS Direct surveillance system is currently unlikely to detect an event similar to the cryptosporidiosis outbreak used here and may be most suited to detecting more widespread rises in syndromes in the community, as previously demonstrated. However, the expected rise in NHS Direct call rates, should improve early warning of outbreaks using call data.

摘要

英国的一个全国性监测系统目前利用一条健康热线(国民保健署直接服务热线)的数据,试图对生物恐怖袭击或由更常见感染引发的疫情提供早期预警。为了测试这个症状监测系统,我们将隐孢子虫病历史疫情的数据叠加到国民保健署直接服务热线呼叫数据的统计模型上。我们模拟了关于腹泻(隐孢子虫病的替代指标)的呼叫是否超过统计阈值,从而提醒监测团队注意疫情。在公共卫生团队首次接到疫情通报的当天,当我们假设隐孢子虫病病例的二十分之一拨打了热线时,我们的模型预测检测到疫情的概率为4%。当我们假设十分之九的病例拨打了热线时,这一概率上升到了72%。国民保健署直接服务热线监测系统目前不太可能检测到与这里所使用的隐孢子虫病疫情类似的事件,并且可能最适合检测社区中综合征更广泛的上升情况,正如之前所证明的那样。然而,国民保健署直接服务热线呼叫率的预期上升,应该会利用呼叫数据改善疫情的早期预警。

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