对气溶胶和肌肉注射百日咳疫苗的呼吸道和体液免疫反应。
Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine.
作者信息
Thomas G
出版信息
J Hyg (Lond). 1975 Apr;74(2):233-7. doi: 10.1017/s0022172400024293.
Abstract
Animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. In this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. Substanial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. The reverse was observed after intramuscular pertussis vaccine in adults but not with aerosol immunization. The latter method may be of value for paediatric medical and nursing personnel exposed to the risk of pertussis infection.
摘要
动物实验表明，呼吸道给予百日咳抗原可诱导保护性免疫反应。在本研究中，检测了人类呼吸道分泌物中的百日咳抗体，并研究了对气溶胶和肌肉注射百日咳免疫的反应。气溶胶免疫后，这种抗体显著增加，但血清抗体未发现变化。在成人中，肌肉注射百日咳疫苗后观察到相反的情况，但气溶胶免疫则没有。后一种方法可能对有百日咳感染风险的儿科医护人员有价值。
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