Kampf Günter, Ennen Joachim
Bode Chemie GmbH & Co., Scientific Affairs, Melanchthonstr. 27, 22525 Hamburg, Germany.
BMC Dermatol. 2006 Feb 13;6:1. doi: 10.1186/1471-5945-6-1.
Aim of the study was to determine the effect of the regular use of a hand cream after washing hands on skin hydration and skin roughness.
Twenty-five subjects washed hands and forearms with a neutral soap four times per day, for 2 minutes each time, for a total of two weeks. One part of them used a hand cream after each hand wash, the others did not (cross over design after a wash out period of two weeks). Skin roughness and skin hydration were determined on the forearms on days 2, 7, 9 and 14. For skin roughness, twelve silicon imprint per subject and time point were taken from the stratum corneum and assessed with a 3D skin analyzer for depth of the skin relief. For skin hydration, five measurements per subject and time point were taken with a corneometer.
Washing hands lead to a gradual increase of skin roughness from 100 (baseline) to a maximum of 108.5 after 9 days. Use of a hand cream after each hand wash entailed a decrease of skin roughness which the lowest means after 2 (94.5) and 14 days (94.8). Skin hydration was gradually decreased after washing hands from 79 (baseline) to 65.5 after 14 days. The hand wash, followed by use of a hand cream, still decreased skin hydration after 2 days (76.1). Over the next 12 days, however, skin hydration did not change significantly (75.6 after 14 days).
Repetitive and frequent hand washing increases skin dryness and roughness. Use of a hand cream immediately after each hand wash can confine both skin dryness and skin roughness. Regular use of skin care preparations should therefore help to prevent both dry and rough skin among healthcare workers in clinical practice.
本研究的目的是确定洗手后定期使用护手霜对皮肤水分和皮肤粗糙度的影响。
25名受试者每天用中性肥皂洗手和前臂4次,每次2分钟,共持续两周。其中一部分人每次洗手后使用护手霜,其他人则不使用(在两周的洗脱期后采用交叉设计)。在第2、7、9和14天测定前臂的皮肤粗糙度和皮肤水分。对于皮肤粗糙度,每个受试者和时间点从角质层采集12个硅印记,并用3D皮肤分析仪评估皮肤纹理深度。对于皮肤水分,每个受试者和时间点用角质层水合测定仪进行5次测量。
洗手导致皮肤粗糙度从100(基线)逐渐增加,在9天后最高达到108.5。每次洗手后使用护手霜会使皮肤粗糙度降低,在第2天(94.5)和第14天(94.8)达到最低值。洗手后皮肤水分从79(基线)逐渐降低,14天后降至65.5。洗手后使用护手霜,在2天后皮肤水分仍会降低(76.1)。然而,在接下来的12天里,皮肤水分没有显著变化(14天后为75.6)。
反复频繁洗手会增加皮肤干燥和粗糙度。每次洗手后立即使用护手霜可以限制皮肤干燥和粗糙度。因此,在临床实践中,定期使用皮肤护理制剂应有助于预防医护人员皮肤干燥和粗糙。