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孕期排出的BK病毒和JC病毒主要具有原型调控区域。

BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions.

作者信息

Markowitz R B, Eaton B A, Kubik M F, Latorra D, McGregor J A, Dynan W S

机构信息

Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.

出版信息

J Virol. 1991 Aug;65(8):4515-9. doi: 10.1128/JVI.65.8.4515-4519.1991.

DOI:10.1128/JVI.65.8.4515-4519.1991
PMID:1649346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248896/
Abstract

Twenty-three BK virus and JC virus DNA samples obtained from urine of pregnant women had almost exclusively archetypal transcriptional control regions. Rearrangements characteristic of laboratory strains are apparently not required for reactivation in humans. Unexpectedly, alignment shows that many elements identified previously in the BK virus enhancer are conserved in the JC virus archetype.

摘要

从孕妇尿液中获取的23份BK病毒和JC病毒DNA样本几乎均具有典型的转录控制区。在人类中重新激活显然不需要实验室菌株特有的重排。出乎意料的是，序列比对显示，BK病毒增强子中先前鉴定出的许多元件在JC病毒原型中是保守的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5388/248896/61dd5abc8e4f/jvirol00051-0556-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5388/248896/237e8f1d894f/jvirol00051-0556-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5388/248896/61dd5abc8e4f/jvirol00051-0556-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5388/248896/237e8f1d894f/jvirol00051-0556-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5388/248896/61dd5abc8e4f/jvirol00051-0556-b.jpg

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本文引用的文献

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Clin Exp Immunol. 1983 Aug;53(2):289-96.
2
Progressive multifocal leucoencephalopathy: detection of papovavirus JC in kidney tissue.进行性多灶性白质脑病：在肾脏组织中检测到乳头多瘤空泡病毒JC
J Med Virol. 1983;11(4):307-17. doi: 10.1002/jmv.1890110406.
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Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues.BK病毒和JC病毒的DNA序列在正常人体组织和患病组织中的持续性。
Virol J. 2021 Jan 22;18(1):24. doi: 10.1186/s12985-021-01496-1.
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Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis.人类多瘤病毒JCPyV及其在进行性多灶性白质脑病和肿瘤发生中的作用。
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Intra-patient viral evolution in polyomavirus-related diseases.多瘤病毒相关性疾病中的患者内病毒进化。
Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180301. doi: 10.1098/rstb.2018.0301.
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J Family Reprod Health. 2018 Jun;12(2):111-116.
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