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乳头瘤病毒DNA在生殖器癌中与myc基因的整合及其对原癌基因表达的影响。

Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression.

作者信息

Couturier J, Sastre-Garau X, Schneider-Maunoury S, Labib A, Orth G

机构信息

Section de Biologie, CNRS URA620, Institut Pasteur, Paris, France.

出版信息

J Virol. 1991 Aug;65(8):4534-8. doi: 10.1128/JVI.65.8.4534-4538.1991.

DOI:10.1128/JVI.65.8.4534-4538.1991
PMID:1649348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248900/
Abstract

DNA sequences of specific human papillomavirus (HPV) types are found integrated in the cell genome in most invasive genital carcinomas. We have determined the chromosomal localization of integrated HPV type 16 (HPV-16) or HPV-18 genomes in genital cancers by in situ hybridization experiments. In three cancers, HPV sequences were localized in chromosome band 8q24.1, in which the c-myc gene is mapped, and in one cancer HPV sequences were localized in chromosome band 2p24, which contains the N-myc gene. In three of the four cases, the proto-oncogene located near integrated viral sequences was found to be structurally altered and/or overexpressed. These data indicate that HPV genomes are preferentially integrated near myc genes in invasive genital cancers and support the hypothesis that integration plays a part in tumor progression via an activation of cellular oncogenes.

摘要

在大多数浸润性生殖器癌中，均可发现特定类型人乳头瘤病毒（HPV）的DNA序列整合于细胞基因组中。我们通过原位杂交实验确定了生殖器癌中整合型HPV16（HPV-16）或HPV-18基因组的染色体定位。在3例癌症中，HPV序列定位于8q24.1染色体带，c-myc基因定位于此；在1例癌症中，HPV序列定位于2p24染色体带，该带含有N-myc基因。在4例中的3例中，发现位于整合病毒序列附近的原癌基因在结构上发生改变和/或过度表达。这些数据表明，在浸润性生殖器癌中，HPV基因组优先整合于myc基因附近，支持整合通过激活细胞癌基因在肿瘤进展中发挥作用这一假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/29c52b068167/jvirol00051-0577-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/1e9a6de413c5/jvirol00051-0575-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/7104c12edd44/jvirol00051-0576-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/313eebf1093a/jvirol00051-0577-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/29c52b068167/jvirol00051-0577-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/1e9a6de413c5/jvirol00051-0575-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/7104c12edd44/jvirol00051-0576-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/313eebf1093a/jvirol00051-0577-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58be/248900/29c52b068167/jvirol00051-0577-b.jpg

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