Liu Jun, Hou Xiaohua, Song Gengqing, Cha Hui, Yang Bin, Chen Jiande D Z
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, Republic of China.
Am J Gastroenterol. 2006 Apr;101(4):798-803. doi: 10.1111/j.1572-0241.2006.00493.x. Epub 2006 Feb 22.
Implantable gastric stimulation (IGS) has been proposed for treating obesity. The aim of this study was to investigate the effects of temporary mucosal electrical stimulation on water and food intake as well as gastric emptying in healthy humans.
The study was designed to study the effects of temporary gastric electrical stimulation (GES) on symptoms, gastric accommodation, food intake, and gastric emptying. It was performed in 12 healthy volunteers on 3 consecutive days. GES was performed using mucosal electrodes endoscopically placed in the fundus.
The amount of maximum water intake was reduced with GES (894 +/- 326 mL) compared with sham-GES (1,093 +/- 417 mL, p = 0.01). The food intake was also reduced with GES (p = 0.012). In comparison with sham stimulation, GES delayed gastric emptying during the first 45 min after the meal but not during the remaining time. GES with parameters effective in reducing water and food intake and delaying gastric emptying did not induce significant dyspeptic symptoms, compared with sham stimulation.
GES using temporary mucosal electrodes decreases food intake as well as maximum intake of water, and has a tendency of delaying gastric emptying. It may have a potential application for the treatment of obesity.
可植入式胃刺激（IGS）已被提出用于治疗肥胖症。本研究的目的是调查临时黏膜电刺激对健康人水和食物摄入量以及胃排空的影响。
本研究旨在研究临时胃电刺激（GES）对症状、胃容纳功能、食物摄入量和胃排空的影响。在12名健康志愿者身上连续进行3天。使用内镜放置在胃底的黏膜电极进行GES。
与假刺激（1093±417毫升，p = 0.01）相比，GES使最大饮水量减少（894±326毫升）。GES也使食物摄入量减少（p = 0.012）。与假刺激相比，GES在餐后前45分钟延迟胃排空，但在其余时间没有延迟。与假刺激相比，具有减少水和食物摄入量以及延迟胃排空有效参数的GES未诱发明显的消化不良症状。
使用临时黏膜电极的GES可减少食物摄入量以及最大饮水量，并具有延迟胃排空的趋势。它可能在肥胖症治疗中具有潜在应用价值。
