Gott Merryn, Barnes Sarah, Parker Chris, Payne Sheila, Seamark David, Gariballa Salah, Small Neil
Sheffield Institute for Studies on Ageing, University of Sheffield, Elmfield, Northumberland Road, Sheffield S10 2TU, UK.
Age Ageing. 2006 Mar;35(2):172-7. doi: 10.1093/ageing/afj040.
Current understanding of quality of life in heart failure is largely derived from clinical trials. Older people, women and those with co-morbidities are underrepresented in these. Little is known about factors predictive of quality of life amongst older people with heart failure recruited from community settings.
To identify factors predictive of quality of life amongst older people recruited from community settings.
prospective questionnaire survey.
General practice surgeries located in four areas of the UK: Bradford, Barnsley, East Devon and West Hampshire.
A total of 542 people aged >60 years with heart failure.
Participants completed a postal questionnaire, which included a disease-specific measure (Kansas City Cardiomyopathy Questionnaire), a generic quality-of-life measure (SF-36) and sociodemographic information.
A multiple linear regression analysis identified the following factors as predictive of decreased quality of life: being female, being in New York Heart Association (NYHA) functional class III or IV, showing evidence of depression, being in socioeconomic groups III-V and experiencing two or more co-morbidities. Older age was associated with decreased quality of life, as measured by a generic health-related quality-of-life tool (the SF-36 mental and physical health functioning scales) but not by a disease-specific tool (the Kansas City Cardiomyopathy Questionnaire).
Findings from the study suggest that quality of life for older people with heart failure can be described as challenging and difficult, particularly for women, those in a high NYHA class, patients showing evidence of depression, patients in socioeconomic groups III-V, those experiencing two or more co-morbidities and the 'oldest old'. Such information can help clinicians working with older people identify those at risk of reduced quality of life and target interventions appropriately.
目前对心力衰竭患者生活质量的认识很大程度上来自临床试验。老年人、女性以及患有合并症的患者在这些试验中的代表性不足。对于从社区招募的老年心力衰竭患者中预测生活质量的因素知之甚少。
确定从社区招募的老年人中预测生活质量的因素。
前瞻性问卷调查。
位于英国四个地区的全科诊所:布拉德福德、巴恩斯利、东德文郡和西汉普郡。
共有542名年龄>60岁的心力衰竭患者。
参与者完成一份邮寄问卷,其中包括一项疾病特异性测量(堪萨斯城心肌病问卷)、一项通用生活质量测量(SF-36)和社会人口统计学信息。
多元线性回归分析确定以下因素可预测生活质量下降:女性、纽约心脏协会(NYHA)功能分级为III或IV级、有抑郁迹象、属于社会经济群体III-V级以及患有两种或更多合并症。年龄较大与生活质量下降相关,这是通过通用的健康相关生活质量工具(SF-36心理和身体健康功能量表)测量得出的,但疾病特异性工具(堪萨斯城心肌病问卷)未显示此关联。
该研究结果表明,老年心力衰竭患者的生活质量具有挑战性且较差,特别是对于女性、NYHA分级较高的患者、有抑郁迹象的患者、社会经济群体III-V级的患者、患有两种或更多合并症的患者以及“最年长的老人”。此类信息可帮助老年患者的临床医生识别生活质量降低风险较高的患者,并进行适当的针对性干预。