Bazelmans Christine, De Henauw Stefaan, Matthys Christof, Dramaix Michel, Kornitzer Marcel, De Backer Guy, Levêque Alain
Dept. of Epidemiology & Health Promotion, School of Public Health, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Bruxelles, Belgium.
Eur J Epidemiol. 2006;21(2):145-52. doi: 10.1007/s10654-005-5699-8.
To develop a Healthy Food and Nutrient Index (HFNI) and to relate this index to the all cause mortality observed in two Belgian communities.
Using the 10-years follow-up mortality data from the 'Belgian Inter-university Research on Nutrition and Health' (BIRNH) study, the association of a Healthy Food and Nutrient Index (HFNI) and all cause mortality was investigated in 5,887 men and 5,306 women aged 25-74 years. The HFNI was developed on the basis of the national dietary guidelines. The higher the index the more the diet can be considered to conform to the recommendations.
After adjustment for classic all cause mortality risk factors, HFNI was related with mortality for men. A decrease in risk of death is noted from Quartile 1 to Quartile 4. Among the women, HFNI remains non-significant. The ability of the models (with and without HFNI) to discriminate the living and the dead was evaluated by constructing a receiver operating characteristic (ROC) curves. For all models, areas under the Roc curves were between 0.80 and 0.85 indicating that all models discriminate well alive subjects of deceased. However, comparison of the areas under the ROC curves of the models without HFNI with the ROC areas of the models with HFNI showed no improvement in our ability to discriminate between the living and the dead.
Although it is not demonstrated in our study, we think that the overall approach offers an opportunity to improve our understanding of the role of diet in the risks of morbidity or mortality associated with the overall dietary pattern rather than some individual foods and nutrients.
制定健康食品与营养指数(HFNI),并将该指数与在比利时两个社区观察到的全因死亡率相关联。
利用“比利时大学间营养与健康研究”(BIRNH)研究的10年随访死亡率数据,在5887名年龄在25至74岁的男性和5306名女性中调查了健康食品与营养指数(HFNI)与全因死亡率之间的关联。HFNI是根据国家饮食指南制定的。该指数越高,饮食就越能被认为符合建议。
在对经典的全因死亡风险因素进行调整后,HFNI与男性死亡率相关。从第一四分位数到第四四分位数,死亡风险降低。在女性中,HFNI仍然不显著。通过构建受试者工作特征(ROC)曲线来评估模型(有和没有HFNI)区分存活者和死亡者的能力。对于所有模型,ROC曲线下的面积在0.80至0.85之间,表明所有模型都能很好地区分存活者和死亡者。然而,比较没有HFNI的模型的ROC曲线下面积与有HFNI的模型的ROC面积,结果显示我们区分存活者和死亡者的能力没有提高。
虽然我们的研究没有证明这一点,但我们认为总体方法为增进我们对饮食在与总体饮食模式相关的发病或死亡风险中的作用的理解提供了一个机会,而不是关注某些单一的食物和营养素。