Lynch L, Daffos F, Emanuel D, Giovangrandi Y, Meisel R, Forestier F, Cathomas G, Berkowitz R L
Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Medical Center, New York, NY 10029.
Am J Obstet Gynecol. 1991 Sep;165(3):714-8. doi: 10.1016/0002-9378(91)90315-i.
Twelve fetuses were evaluated with a combination of ultrasonography, amniocentesis, and blood sampling for possible cytomegalovirus infection. In seven the mother had a documented primary cytomegalovirus infection. All seven women had normal ultrasonographic findings and one fetus was found to be infected. In the other five cases fetal cytomegalovirus infection was diagnosed in association with abnormal ultrasonographic findings. There was no history of maternal infection in the latter group. All positive and negative diagnoses were confirmed and none of the six infected fetuses survived. In this series, the most reliable parameters of infection were the isolation of the virus from amniotic fluid and elevations of total immunoglobulin M and gamma-glutamyl transpeptidase in fetal blood. In the majority of infected fetuses cytomegalovirus-specific immunoglobulin M was not detected in blood. Prenatal diagnosis of fetal cytomegalovirus infection is possible with a combination of amniocentesis and fetal blood sampling.
对12例胎儿进行了超声检查、羊膜穿刺术和血液采样相结合的检查，以评估是否可能感染巨细胞病毒。其中7例母亲有记录的原发性巨细胞病毒感染。所有7名女性超声检查结果均正常，发现1例胎儿感染。在其他5例中，胎儿巨细胞病毒感染与超声检查异常有关。后一组中没有母亲感染史。所有阳性和阴性诊断均得到证实，6例感染胎儿均未存活。在该系列中，最可靠的感染参数是从羊水中分离出病毒以及胎儿血液中总免疫球蛋白M和γ-谷氨酰转肽酶升高。在大多数感染胎儿的血液中未检测到巨细胞病毒特异性免疫球蛋白M。联合羊膜穿刺术和胎儿血液采样可进行胎儿巨细胞病毒感染的产前诊断。
