2型单纯疱疹病毒潜伏相关转录本编码基因的核苷酸序列、5'端、启动子结构域及表达动力学
The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.
作者信息
Krause P R, Ostrove J M, Straus S E
机构信息
Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
出版信息
J Virol. 1991 Oct;65(10):5619-23. doi: 10.1128/JVI.65.10.5619-5623.1991.
The sequence of the herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) region resembles that of HSV-1 only where the LATs overlap ICP0 and in the putative promoter region. Otherwise, the LAT 5' ends, kinetics of expression, and promoter elements are mostly conserved between HSV-1 and HSV-2. The remaining differences between the LATs could contribute to each virus's distinctive pattern of reactivation.
2型单纯疱疹病毒（HSV - 2）潜伏相关转录物（LAT）区域的序列仅在LAT与ICP0重叠处以及推定的启动子区域与HSV - 1相似。否则，HSV - 1和HSV - 2之间的LAT 5'端、表达动力学和启动子元件大多是保守的。LAT之间的其余差异可能导致每种病毒独特的再激活模式。
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