基于核酸同源性的遗传分化II. 两种支原体物种内的基因型变异
Genetic Differentiation by Nucleic Acid Homology II. Genotypic Variations Within Two Mycoplasma Species.
作者信息
Somerson N L, Reich P R, Walls B E, Chanock R M, Weissman S M
机构信息
National Institute of Allergy and Infectious Diseases, and Metabolism Service, National Cancer Institute, U.S. Public Health Service, Bethesda, Maryland.
出版信息
J Bacteriol. 1966 Aug;92(2):311-7. doi: 10.1128/jb.92.2.311-317.1966.
Somerson, Norman L. (National Institutes of Health, Bethesda, Md.), Paul R. Reich, Barbara E. Walls, Robert M. Chanock, and Sherman M. Weissman. Genetic differentiation by nucleic acid homology. II. Genotypic variations within two Mycoplasma species. J. Bacteriol. 92:311-317. 1966.-A deoxyribonucleic-ribonucleic acid (DNA-RNA) homology technique was used to determine genetic relatedness among the nucleic acids of eight mycoplasmas which were serologically classified as Mycoplasma hominis type 1. The DNA preparations from these organisms were each found to be distinct. No subgrouping of the M. hominis type 1 strains could be demonstrated. In contrast, when the nucleic acids from six serologically related mycoplasmas which were isolated from tissue cultures were studied, the DNA from these species could not be distinguished. The DNA buoyant densities of the tissue culture isolates were similar. These isolates were closely related genetically to a porcine mycoplasma, M. hyorhinis.
索默森，诺曼·L.（国立卫生研究院，马里兰州贝塞斯达），保罗·R.赖克，芭芭拉·E.沃尔斯，罗伯特·M.查诺克，以及谢尔曼·M.魏斯曼。通过核酸同源性进行遗传分化。II. 两种支原体物种内的基因型变异。《细菌学杂志》92:311 - 317。1966年。——采用脱氧核糖核酸 - 核糖核酸（DNA - RNA）同源性技术来确定八种支原体核酸之间的遗传相关性，这些支原体在血清学上被归类为人型支原体1型。发现这些生物体的DNA制剂各不相同。无法证明人型支原体1型菌株存在亚群划分。相比之下，当研究从组织培养物中分离出的六种血清学相关支原体的核酸时，这些物种的DNA无法区分。组织培养物分离株的DNA浮力密度相似。这些分离株在遗传上与猪支原体猪鼻支原体密切相关。
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