Deans Anne-Marie, Lyke Kirsten E, Thera Mahamadou A, Plowe Christopher V, Koné Abdoulaye, Doumbo Ogobara K, Kai Oscar, Marsh Kevin, Mackinnon Margaret J, Raza Ahmed, Rowe J Alexandra
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Am J Trop Med Hyg. 2006 Apr;74(4):554-63.
Two potential malaria virulence factors, parasite multiplication rate (PMR) and red blood cell selectivity (measured as selectivity index [SI]), were assessed in Plasmodium falciparum clinical isolates from Mali and Kenya. At both sites, PMRs were low (Kenya median = 2.2, n = 33; Mali median = 2.6, n = 61) and did not differ significantly between uncomplicated and severe malaria cases. Malian isolates from hyperparasitemic patients had significantly lower PMRs (median = 1.8, n = 19) than other Malian isolates (uncomplicated malaria median = 3.1, n = 23; severe malaria median = 2.8, n = 19; P = 0.03, by Kruskal-Wallis test). Selective invasion occurred at both sites (Kenya geometric mean SI = 1.9, n = 98; Mali geometric mean SI = 1.6, n = 104), and there was no significant association between the SI and malaria severity. Therefore, in contrast to previous results from Thailand, we found no association of PMR and SI with malaria severity in African children. This raises the possibility of differences in the mechanisms of malaria virulence between sub-Saharan Africa and Asia.
对来自马里和肯尼亚的恶性疟原虫临床分离株评估了两个潜在的疟疾毒力因子，即寄生虫增殖率（PMR）和红细胞选择性（以选择性指数[SI]衡量）。在这两个地点，PMR均较低（肯尼亚中位数 = 2.2，n = 33；马里中位数 = 2.6，n = 61），且单纯性疟疾和重症疟疾病例之间无显著差异。来自高疟原虫血症患者的马里分离株的PMR（中位数 = 1.8，n = 19）显著低于其他马里分离株（单纯性疟疾中位数 = 3.1，n = 23；重症疟疾中位数 = 2.8，n = 19；经Kruskal-Wallis检验，P = 0.03）。在这两个地点均发生了选择性侵袭（肯尼亚几何平均SI = 1.9，n = 98；马里几何平均SI = 1.6，n = 104），且SI与疟疾严重程度之间无显著关联。因此，与泰国先前的结果相反，我们发现在非洲儿童中PMR和SI与疟疾严重程度无关联。这增加了撒哈拉以南非洲和亚洲之间疟疾毒力机制存在差异的可能性。
