Tan Ava Grace, Wang Jie Jin, Rochtchina Elena, Mitchell Paul
Centre for Vision Research, Westmead Millennium Institute, Department of Ophthalmology, University of Sydney, Westmead Hospital, Westmead, NSW, Australia.
BMC Ophthalmol. 2006 Apr 20;6:17. doi: 10.1186/1471-2415-6-17.
In this study, we aimed to compare age-specific cortical, nuclear and posterior subcapsular (PSC) cataract prevalence in two surveys 6 years apart.
The Blue Mountains Eye Study examined 3654 participants (82.4% of those eligible) in cross-section I (1992-4) and 3509 participants (75.1% of survivors and 85.2% of newly eligible) in cross-section II (1997-2000, 66.5% overlap with cross-section I). Cataract was assessed from lens photographs following the Wisconsin Cataract Grading System. Cortical cataract was defined if cortical opacity comprised > or = 5% of lens area. Nuclear cataract was defined if nuclear opacity > or = Wisconsin standard 4. PSC was defined if any present. Any cataract was defined to include persons who had previous cataract surgery. Weighted kappa for inter-grader reliability was 0.82, 0.55 and 0.82 for cortical, nuclear and PSC cataract, respectively. We assessed age-specific prevalence using an interval of 5 years, so that participants within each age group were independent between the two surveys.
Age and gender distributions were similar between the two populations. The age-specific prevalence of cortical (23.8% in 1st, 23.7% in 2nd) and PSC cataract (6.3%, 6.0%) was similar. The prevalence of nuclear cataract increased slightly from 18.7% to 23.9%. After age standardization, the similar prevalence of cortical (23.8%, 23.5%) and PSC cataract (6.3%, 5.9%), and the increased prevalence of nuclear cataract (18.7%, 24.2%) remained.
In two surveys of two population-based samples with similar age and gender distributions, we found a relatively stable cortical and PSC cataract prevalence over a 6-year period. The increased prevalence of nuclear cataract deserves further study.
在本研究中,我们旨在比较相隔6年的两项调查中不同年龄段皮质性、核性和后囊下(PSC)白内障的患病率。
蓝山眼研究在第一阶段(1992 - 1994年)检查了3654名参与者(占符合条件者的82.4%),在第二阶段(1997 - 2000年,与第一阶段有66.5%的重叠)检查了3509名参与者(占幸存者的75.1%和新符合条件者的85.2%)。根据威斯康星白内障分级系统,通过晶状体照片评估白内障。如果皮质混浊占晶状体面积的≥5%,则定义为皮质性白内障。如果核混浊≥威斯康星标准4,则定义为核性白内障。如果存在任何PSC,则定义为PSC白内障。任何白内障定义为包括曾接受白内障手术的人。皮质性、核性和PSC白内障分级者间可靠性的加权kappa分别为0.82、0.55和0.82。我们使用5年的间隔评估特定年龄段的患病率,以便每个年龄组内的参与者在两次调查之间相互独立。
两个人群的年龄和性别分布相似。皮质性白内障(第一阶段为23.8%,第二阶段为23.7%)和PSC白内障(6.3%,6.0%)的特定年龄段患病率相似。核性白内障的患病率从18.7%略有增加至23.9%。年龄标准化后,皮质性(23.8%,23.5%)和PSC白内障(6.3%,5.9%)的患病率相似,核性白内障的患病率增加(18.7%,24.2%)仍然存在。
在对两个人群样本进行的两次调查中,年龄和性别分布相似,我们发现在6年期间皮质性和PSC白内障的患病率相对稳定。核性白内障患病率的增加值得进一步研究。