Gelhorn Heather, Stallings Michael, Young Susan, Corley Robin, Rhee Soo Hyun, Christian Hopfer, Hewitt John
Drs. Gelhorn, Stallings, Young, Corley, Rhee, and Hewitt are with the Institute for Behavioral Genetics, University of Colorado, Boulder; Dr. Hopfer is with the Psychiatry Department, University of Colorado Health Sciences Center, Denver.
Drs. Gelhorn, Stallings, Young, Corley, Rhee, and Hewitt are with the Institute for Behavioral Genetics, University of Colorado, Boulder; Dr. Hopfer is with the Psychiatry Department, University of Colorado Health Sciences Center, Denver.
J Am Acad Child Adolesc Psychiatry. 2006 May;45(5):570-577. doi: 10.1097/01.chi.0000198596.76443.b0.
To explore the genetic and environmental influences on DSM-IV conduct disorder (CD) aggressive and nonaggressive subscales, taking into account age and sex differences.
A community sample of 1,100 twin pairs (ages 11-18) was interviewed using the Diagnostic Interview Schedule for Children. Bivariate analyses, using variable threshold models accounting for age and sex differences, were used to determine the extent to which the genetic and environmental influences on aggressive and nonaggressive CD domains are shared or unique.
The phenotypic correlation between aggressive and nonaggressive CD domains was 0.32. The most parsimonious bivariate model included additive genetic effects and nonshared environmental effects only (AE model).
The results of behavior genetic model fitting suggest that the DSM-IV CD domains are influenced by unique genetic and environmental factors, but also share some common genetic and environmental influences. A large percentage of the covariation (61%) is caused by genetic factors. These results are consistent with a previous report on the bivariate heritability of aggressive and nonaggressive antisocial behavior, but extend the findings to DSM-IV domains.
考虑年龄和性别差异，探讨遗传和环境对《精神疾病诊断与统计手册》第四版（DSM-IV）品行障碍（CD）攻击型和非攻击型分量表的影响。
使用儿童诊断访谈量表对1100对双胞胎（年龄11 - 18岁）的社区样本进行访谈。采用双变量分析，运用考虑年龄和性别差异的可变阈值模型，以确定遗传和环境对攻击型和非攻击型CD领域的影响在多大程度上是共享的或独特的。
攻击型和非攻击型CD领域之间的表型相关性为0.32。最简约的双变量模型仅包括加性遗传效应和非共享环境效应（AE模型）。
行为遗传模型拟合结果表明，DSM-IV CD领域受独特的遗传和环境因素影响，但也存在一些共同的遗传和环境影响。很大一部分协变（61%）是由遗传因素引起的。这些结果与先前关于攻击型和非攻击型反社会行为双变量遗传度的报告一致，但将研究结果扩展到了DSM-IV领域。
