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饮食限制对灵长类动物有效吗?

Will dietary restriction work in primates?

作者信息

Weindruch Richard

机构信息

Department of Medicine, University of Wisconsin and Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.

出版信息

Biogerontology. 2006 Jun;7(3):169-71. doi: 10.1007/s10522-006-9007-0.

Abstract

This issue of Biogerontology addresses whether dietary restriction (DR) "...can increase longevity in all species, particularly in human beings". The possibility that DR can increase longevity in all species seems a trivial issue compared to that of DR's potential efficacy in people. The striking phylogenetic breadth of DR's longevity increasing effect supports the notion of human translatability. The available evidence in primates (human and nonhuman) suggests that it is highly probable that DR will increase the span of good health (and the average lifespan) but the magnitude of this predicted increase is unknown. Robust survival data for monkeys subjected to highly controlled DR will be available in approximately 25 years; similar data for large numbers of human practitioners of DR appear to be many decades away.

摘要

本期《生物老年学》探讨了饮食限制(DR)“……是否能延长所有物种的寿命,尤其是人类的寿命”。与饮食限制对人类的潜在功效相比,饮食限制能否延长所有物种的寿命这一问题似乎微不足道。饮食限制延长寿命的效应在系统发育上具有显著的广度,这支持了其对人类具有可转化性的观点。灵长类动物(包括人类和非人类)的现有证据表明,饮食限制很有可能会延长健康期(以及平均寿命),但这种预期延长的幅度尚不清楚。在大约25年后将可获得经过高度控制的饮食限制的猴子的可靠生存数据;而大量实行饮食限制的人类的类似数据似乎还需要几十年才能获得。

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