Astete Carlos E, Sabliov Cristina M
Department of Biological and Agricultural Engineering, Louisiana State University Agricultural Center, Baton Rouge 70803, USA.
J Biomater Sci Polym Ed. 2006;17(3):247-89. doi: 10.1163/156856206775997322.
Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques available for PLGA nanoparticle formation, as well as the techniques commonly used for nanoparticle characterization. Many examples are discussed in detail to provide the reader with an extensive knowledge base on the important parameters specific to the synthesis method described and ways in which these parameters can be manipulated to control the nanoparticle physical characteristics.
通过控制特定合成方法的参数，可以合成具有不同物理特性（尺寸、尺寸分布、形态、zeta电位）的聚（丙交酯-共-乙交酯）（PLGA）纳米颗粒。本综述的目的是清晰、定量且全面地描述可用于形成PLGA纳米颗粒的自上而下合成技术，以及常用于纳米颗粒表征的技术。详细讨论了许多实例，为读者提供关于所述合成方法特定重要参数的广泛知识库，以及操纵这些参数以控制纳米颗粒物理特性的方法。
