Spoerke Erik D, Murray Naomi G, Li Huanlong, Brinson L Catherine, Dunand David C, Stupp Samuel I
Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
Acta Biomater. 2005 Sep;1(5):523-33. doi: 10.1016/j.actbio.2005.04.005. Epub 2005 Jul 14.
While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.
虽然钛作为骨科或牙科植入材料在临床上已取得成功，但与植入物-骨界面强度以及钛与组织之间的机械模量不匹配相关的性能问题仍然存在。我们在此描述了一种泡沫钛的制备方法，它能更好地与组织实现机械匹配，其表面通过沉积有机改性磷灰石层（有机磷灰石）而对骨细胞具有吸引力。在旋转生物反应器中，这些涂覆有有机磷灰石的泡沫成功地被前成骨细胞定植。有限元分析表明，这些系统中向内生长的组织可通过负载分担和应力分布来改善植入物性能和组织形成。这里描述的新型金属-陶瓷-聚合物复合材料在骨组织工程方面具有巨大潜力。
