Riemersma R A, Wood D A, Macintyre C C, Elton R A, Gey K F, Oliver M F
Department of Cardiology, University of Edinburgh.
Lancet. 1991 Jan 5;337(8732):1-5. doi: 10.1016/0140-6736(91)93327-6.
The relation between risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene was examined in a population case-control study of 110 cases of angina, identified by the Chest Pain Questionnaire, and 394 controls selected from a sample of 6000 men aged 35-54. Plasma concentrations of vitamins C and E and carotene were significantly inversely related to the risk of angina. There was no significant relation with vitamin A. Smoking was a confounding factor. The inverse relation between angina and low plasma carotene disappeared and that with plasma vitamin C was substantially reduced after adjustment for smoking. Vitamin E remained independently and inversely related to the risk of angina after adjustment for age, smoking habit, blood pressure, lipids, and relative weight. The adjusted odds ratio for angina between the lowest and highest quintiles of vitamin E concentrations was 2.68 (95% confidence interval 1.07-6.70; p = 0.02). These findings suggest that some populations with a high incidence of coronary heart disease may benefit from eating diets rich in natural antioxidants, particularly vitamin E.
在一项人群病例对照研究中，对心绞痛风险与维生素A、C、E以及胡萝卜素的血浆浓度之间的关系进行了研究。该研究纳入了110例通过胸痛问卷确诊的心绞痛病例，以及从6000名年龄在35 - 54岁男性样本中选取的394名对照。维生素C、E以及胡萝卜素的血浆浓度与心绞痛风险显著呈负相关。与维生素A无显著关系。吸烟是一个混杂因素。在对吸烟进行校正后，心绞痛与低血浆胡萝卜素之间的负相关消失，与血浆维生素C之间的负相关也大幅减弱。在对年龄、吸烟习惯、血压、血脂以及相对体重进行校正后，维生素E仍独立且与心绞痛风险呈负相关。维生素E浓度最低和最高五分位数组之间心绞痛的校正比值比为2.68（95%置信区间1.07 - 6.70；p = 0.02）。这些发现表明，一些冠心病发病率高的人群可能会从富含天然抗氧化剂，特别是维生素E的饮食中获益。
