活化的Hox-2.4同源框基因在小鼠成纤维细胞中的致癌潜力。
The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts.
作者信息
Aberdam D, Negreanu V, Sachs L, Blatt C
机构信息
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.
出版信息
Mol Cell Biol. 1991 Jan;11(1):554-7. doi: 10.1128/mcb.11.1.554-557.1991.
The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.
同源框基因Hox-2.4在小鼠髓性白血病WEHI-3B细胞中被转录激活。WEHI-3B细胞中Hox-2.4的组成性表达是由于一个属于A颗粒顺式内的转座元件的插入。在本研究中，我们证明了这个激活的同源框基因的致癌潜力。携带激活的Hox-2.4基因的NIH 3T3成纤维细胞克隆在裸鼠中产生了纤维肉瘤。
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