Jansson-Nettelbladt Evelyn, Meurling Staffan, Petrini Björn, Sjölin Jan
Section of Infectious Diseases, Department of Medical Sciences, University Hospital, Uppsala, Sweden.
Acta Paediatr. 2006 Apr;95(4):502-4. doi: 10.1080/08035250500501625.
The term "auto-brewery syndrome" has been frequently used to describe patients who show features of alcohol intoxication because of abnormal yeast proliferation after ingesting carbohydrate-rich meals. We present a case of a 3-y-old girl with short bowel syndrome (SBS) who demonstrated signs of alcohol intoxication on repeated occasions. A blood test indicated an ethanol concentration of 15 mmol/l, and cultures from gastric fluid and faeces showed the presence of Candida kefyr. An association was found between the introduction of a carbohydrate-rich fruit drink and the occurrence of symptoms.
The possibility of endogenous ethanol fermentation should be considered in patients with SBS and the diagnosis of auto-brewery syndrome added to the differential diagnosis list for D-lactic acidosis. Management includes both antifungal treatment and special diet modification.
“自动酿酒综合征”一词常被用于描述那些在摄入富含碳水化合物的餐后因异常酵母增殖而出现酒精中毒特征的患者。我们报告一例3岁短肠综合征（SBS）女童，她多次出现酒精中毒迹象。血液检测显示乙醇浓度为15 mmol/l，胃液和粪便培养显示存在凯氏假丝酵母。发现富含碳水化合物的果汁饮料的引入与症状的出现之间存在关联。
对于短肠综合征患者应考虑内源性乙醇发酵的可能性，并将自动酿酒综合征的诊断添加到D-乳酸酸中毒的鉴别诊断清单中。治疗包括抗真菌治疗和特殊饮食调整。
